The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan
Background and objectives: Lipoproteins mainly LDL-C and Non HDL-C are among important risk factors for coronary atherosclerosis, Coronary angiography is the standard diagnostic investigation for obstructive coronary vascular disease. Finding a lipoprotein index for severity of coronary atheroscler...
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Kurdistan Higher Council Of Medical Specialties
2023-04-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/176 |
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| author | Marewan Hawil Saka Abdulsatar Kamil Faeq |
| author_facet | Marewan Hawil Saka Abdulsatar Kamil Faeq |
| author_sort | Marewan Hawil Saka |
| collection | DOAJ |
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Background and objectives: Lipoproteins mainly LDL-C and Non HDL-C are among important risk factors for coronary atherosclerosis, Coronary angiography is the standard diagnostic investigation for obstructive coronary vascular disease. Finding a lipoprotein index for severity of coronary atherosclerosis which can be estimated by many score systems is matter of debate among many studies. The objective of the study is to assess the effects of different lipoproteins on severity of coronary atherosclerosis and the relation among them.
Methods:From 1-4-2017 to 28- 2-2018, 125 patients collected in Cardiac Center in Erbil were included in this case control study, the patients were collected on daily base by systematic sampling, for all patients basic demographic data collected including age, gender, ethnic group, if he used statin for more than 3 weeks, the risk factors of atherosclerosis , then standard diagnostic coronary angiography done and fasting total serum cholesterol, low density lipoprotein-C, high density lipoprotein-C, serum triglyceride and non-high density lipoprotein-C were estimated, the severity of coronary atherosclerosis were estimated by Syntax score available on line (http://syntaxscore.com/calculator/start.htm), patients were divided to three groups according to their score levels, the data analyzed by SPSS program.
Results : The study showed that there were no significant differences in the demographic data among the three groups apart from the risk factors, mean ages were (57±11, 59±10 and 61±9 year respectively p-value 0.152), male/female ratio were ( 20/20, 36/8 and31/10 respectively p-value 0.558), The study showed that statins significantly reduced cholesterol (p-value 0.03) and low density lipoprotein ( p-value < 0.001) (albeit above target levels) but they did not reduce significantly the non- high density lipoprotein level ( p-value 0.07) nor they reduced the score values significantly ( p-value 0.32). There was significant positive correlation between high density lipoprotein level and the severity of coronary atherosclerosis in all arms.
Conclusions:Serum level of non-high density lipoprotein is more important than low density lipoprotein as far as severity of coronary atherosclerosis is concerned and target LDL level was not achieved
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| format | Article |
| id | doaj-art-7cbe6b112fad40e3bcc8208a8e48320d |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-7cbe6b112fad40e3bcc8208a8e48320d2025-08-20T02:11:58ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802023-04-014210.56056/amj.2018.67177The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in KurdistanMarewan Hawil Saka0Abdulsatar Kamil Faeq1Lecturer in Department of Medicine College of Medicine HMU, Interventional cardiologist at Erbil Cardiac Center Lecturer in Department of Medicine College of Medicine HMU, Trainee in interventional cardiology Erbil Cardiac Center Background and objectives: Lipoproteins mainly LDL-C and Non HDL-C are among important risk factors for coronary atherosclerosis, Coronary angiography is the standard diagnostic investigation for obstructive coronary vascular disease. Finding a lipoprotein index for severity of coronary atherosclerosis which can be estimated by many score systems is matter of debate among many studies. The objective of the study is to assess the effects of different lipoproteins on severity of coronary atherosclerosis and the relation among them. Methods:From 1-4-2017 to 28- 2-2018, 125 patients collected in Cardiac Center in Erbil were included in this case control study, the patients were collected on daily base by systematic sampling, for all patients basic demographic data collected including age, gender, ethnic group, if he used statin for more than 3 weeks, the risk factors of atherosclerosis , then standard diagnostic coronary angiography done and fasting total serum cholesterol, low density lipoprotein-C, high density lipoprotein-C, serum triglyceride and non-high density lipoprotein-C were estimated, the severity of coronary atherosclerosis were estimated by Syntax score available on line (http://syntaxscore.com/calculator/start.htm), patients were divided to three groups according to their score levels, the data analyzed by SPSS program. Results : The study showed that there were no significant differences in the demographic data among the three groups apart from the risk factors, mean ages were (57±11, 59±10 and 61±9 year respectively p-value 0.152), male/female ratio were ( 20/20, 36/8 and31/10 respectively p-value 0.558), The study showed that statins significantly reduced cholesterol (p-value 0.03) and low density lipoprotein ( p-value < 0.001) (albeit above target levels) but they did not reduce significantly the non- high density lipoprotein level ( p-value 0.07) nor they reduced the score values significantly ( p-value 0.32). There was significant positive correlation between high density lipoprotein level and the severity of coronary atherosclerosis in all arms. Conclusions:Serum level of non-high density lipoprotein is more important than low density lipoprotein as far as severity of coronary atherosclerosis is concerned and target LDL level was not achieved https://amj.khcms.edu.krd/index.php/main/article/view/176Coronary atherosclerosisNon high density lipoproteinSyntax score |
| spellingShingle | Marewan Hawil Saka Abdulsatar Kamil Faeq The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan Advanced Medical Journal Coronary atherosclerosis Non high density lipoprotein Syntax score |
| title | The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan |
| title_full | The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan |
| title_fullStr | The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan |
| title_full_unstemmed | The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan |
| title_short | The Effect of Different Lipoproteins on the Severity of Coronary Atherosclerosis and Relation between them in Patients in Kurdistan |
| title_sort | effect of different lipoproteins on the severity of coronary atherosclerosis and relation between them in patients in kurdistan |
| topic | Coronary atherosclerosis Non high density lipoprotein Syntax score |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/176 |
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