Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis

Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis

Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive growth and metastasis, partly driven by fibroblast-mediated stromal interactions. Using RNA sequencing of fibroblasts from early-stage KPC mouse models, we identified significant upregulation of genes involved in adipoge...

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Main Authors: Nupur Ohri, Johanna Häußler, Nino Javakhishvili, David Vieweg, Anais Zourelidis, Bogusz Trojanowicz, Monika Haemmerle, Irene Esposito, Markus Glaß, Yoshiaki Sunami, Jörg Kleeff
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Biological sciences
Genetics
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027998
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