Association of ethylene oxide exposure and obstructive sleep apnea
Background: Ethylene oxide (EO) is a widely utilized industrial compound known to pose health hazards. Although its carcinogenic characteristics have been thoroughly investigated, recent findings indicate possible links to respiratory disease. The correlation between EO exposure and the likelihood o...
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Komiyama Printing Co. Ltd
2025-02-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | https://www.jstage.jst.go.jp/article/ehpm/30/0/30_24-00248/_html/-char/en |
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| author | Shanni Ma Shangfen Xie |
| author_facet | Shanni Ma Shangfen Xie |
| author_sort | Shanni Ma |
| collection | DOAJ |
| description | Background: Ethylene oxide (EO) is a widely utilized industrial compound known to pose health hazards. Although its carcinogenic characteristics have been thoroughly investigated, recent findings indicate possible links to respiratory disease. The correlation between EO exposure and the likelihood of developing obstructive sleep apnea (OSA) in individuals remains unclear. The study aimed to explore the association between EO exposure and OSA within the broader US population. Methods: From 2015 to 2020, 4355 participants were analyzed cross-sectionally in the National Health and Nutrition Examination Survey (NHANES). As the primary indicator of EO exposure, hemoglobin adducts of EO (HbEO) were used in this study. The relationship between EO exposure and OSA prevalence was assessed using weighted multivariable regression analysis and smoothing curve fitting. Using subgroup analysis and interaction tests, we investigated whether this association remained consistent across populations. Results: According to the study, higher HbEO level was positively correlated with a higher prevalence of OSA. Compared to the first HbEO quartile (Q1), participants within the highest quartile (Q4) presented a higher OSA prevalence in the fully model (OR = 1.32, 95% CI: 1.08–1.62, P = 0.01, P for trend = 0.001). This correlation was particularly evident among females and individuals who are insufficiently physically active. Conclusions: This research found a positive relationship between the extent of exposure to EO and OSA prevalence among a representative sample of Americans. |
| format | Article |
| id | doaj-art-7cb53b8d0b344035bb835cb565f13d8d |
| institution | DOAJ |
| issn | 1342-078X 1347-4715 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj-art-7cb53b8d0b344035bb835cb565f13d8d2025-08-20T02:54:54ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152025-02-01309910.1265/ehpm.24-00248ehpmAssociation of ethylene oxide exposure and obstructive sleep apneaShanni Ma0Shangfen Xie1https://orcid.org/0009-0002-0195-9179Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo UniversityDepartment of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Ningbo UniversityBackground: Ethylene oxide (EO) is a widely utilized industrial compound known to pose health hazards. Although its carcinogenic characteristics have been thoroughly investigated, recent findings indicate possible links to respiratory disease. The correlation between EO exposure and the likelihood of developing obstructive sleep apnea (OSA) in individuals remains unclear. The study aimed to explore the association between EO exposure and OSA within the broader US population. Methods: From 2015 to 2020, 4355 participants were analyzed cross-sectionally in the National Health and Nutrition Examination Survey (NHANES). As the primary indicator of EO exposure, hemoglobin adducts of EO (HbEO) were used in this study. The relationship between EO exposure and OSA prevalence was assessed using weighted multivariable regression analysis and smoothing curve fitting. Using subgroup analysis and interaction tests, we investigated whether this association remained consistent across populations. Results: According to the study, higher HbEO level was positively correlated with a higher prevalence of OSA. Compared to the first HbEO quartile (Q1), participants within the highest quartile (Q4) presented a higher OSA prevalence in the fully model (OR = 1.32, 95% CI: 1.08–1.62, P = 0.01, P for trend = 0.001). This correlation was particularly evident among females and individuals who are insufficiently physically active. Conclusions: This research found a positive relationship between the extent of exposure to EO and OSA prevalence among a representative sample of Americans.https://www.jstage.jst.go.jp/article/ehpm/30/0/30_24-00248/_html/-char/enethylene oxideobstructive sleep apneanhanesepidemiology |
| spellingShingle | Shanni Ma Shangfen Xie Association of ethylene oxide exposure and obstructive sleep apnea Environmental Health and Preventive Medicine ethylene oxide obstructive sleep apnea nhanes epidemiology |
| title | Association of ethylene oxide exposure and obstructive sleep apnea |
| title_full | Association of ethylene oxide exposure and obstructive sleep apnea |
| title_fullStr | Association of ethylene oxide exposure and obstructive sleep apnea |
| title_full_unstemmed | Association of ethylene oxide exposure and obstructive sleep apnea |
| title_short | Association of ethylene oxide exposure and obstructive sleep apnea |
| title_sort | association of ethylene oxide exposure and obstructive sleep apnea |
| topic | ethylene oxide obstructive sleep apnea nhanes epidemiology |
| url | https://www.jstage.jst.go.jp/article/ehpm/30/0/30_24-00248/_html/-char/en |
| work_keys_str_mv | AT shannima associationofethyleneoxideexposureandobstructivesleepapnea AT shangfenxie associationofethyleneoxideexposureandobstructivesleepapnea |