The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty
Introduction Instability of the total hip arthroplasty is a common complication and an indication for revision arthroplasty. The implant instability is diagnosed as aseptic with no microbiological culture growth to be obtained through preoperative synovial aspiration. Etiological interpretation of...
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Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
2025-08-01
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| Series: | Гений oртопедии |
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| author | Stanislav A. Linnik Elena A. Orishak Artem M. Ermakov Ivan O. Kucheev Lyudmila Yu. Nilova Evgenii M. Fadeev Giorgi Karagezov Dmitrii Yu. Korshunov Yaroslav B. Tsololo Vadim V. Usikov Andrey V. Polikarpov |
| author_facet | Stanislav A. Linnik Elena A. Orishak Artem M. Ermakov Ivan O. Kucheev Lyudmila Yu. Nilova Evgenii M. Fadeev Giorgi Karagezov Dmitrii Yu. Korshunov Yaroslav B. Tsololo Vadim V. Usikov Andrey V. Polikarpov |
| author_sort | Stanislav A. Linnik |
| collection | DOAJ |
| description | Introduction Instability of the total hip arthroplasty is a common complication and an indication for revision
arthroplasty. The implant instability is diagnosed as aseptic with no microbiological culture growth to be
obtained through preoperative synovial aspiration. Etiological interpretation of intraoperative findings
in cases of so-called "aseptic instability" is critical for determining subsequent treatment strategies.
The objective was to determine the role of microbiological methods in diagnosing periprosthetic joint
infection (PJI) of the hip.
Material and methods A bacteriological analysis was produced for 173 patients with aseptic instability
of total hip replacement. The patients aged 27 to 82 years. Based on laboratory, clinical and microbiological
(MB) findings, the patients were divided into two groups. The first group consisted of 118 (68.2 %) patients
who underwent one-stage revision and had a favorable postoperative prognosis. The second group consisted
of 55 (31.8 %) patients with elevated hematological parameters, local signs of inflammation, positive MB
findings and had unfavorable prognosis. These patients underwent two-stage revision arthroplasty. Biopsy
samples were tested using polymerase chain reaction (PCR) in cases of minimal microbial load.
Results Positive MB results were registered in 5.1 % of patients in the first group and in 25.5 % of patients
in the second group. Intraoperative biopsies revealed positive results in 20.3 % of the first group and 30.9 %
of the second group. PCR identified PJI in 7.5 % of MB biopsies and in 19.6 % of aspirates.
Discussion The findings indicated low diagnostic value of microbiological cultures with PCR improving
diagnostic accuracy by 7.5 %. Detection of low-virulence microorganisms including coagulase-negative
staphylococci required specific evaluation criteria.
Conclusion Microbiological culturing demonstrated moderate sensitivity, in low-virulence infections,
in particular, while PCR in low-virulence infections was essential in establishing the microbial etiology of PJI. |
| format | Article |
| id | doaj-art-7cac4e7ace7e45e493763fad3206a256 |
| institution | Kabale University |
| issn | 1028-4427 2542-131X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics |
| record_format | Article |
| series | Гений oртопедии |
| spelling | doaj-art-7cac4e7ace7e45e493763fad3206a2562025-08-20T06:21:22ZengRussian Ilizarov Scientific Center for Restorative Traumatology and OrthopaedicsГений oртопедии1028-44272542-131X2025-08-0131445246210.18019/1028-4427-2025-31-4-452-462The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplastyStanislav A. Linnik0https://orcid.org/0000-0002-4840-6662Elena A. Orishak1https://orcid.org/0000-0002-4562-4402Artem M. Ermakov2https://orcid.org/0000-0002-5420-4637Ivan O. Kucheev3https://orcid.org/0000-0001-8557-8431Lyudmila Yu. Nilova4https://orcid.org/0009-0005-8898-9152Evgenii M. Fadeev5https://orcid.org/0000-0002-8428-0876Giorgi Karagezov6https://orcid.org/0000-0002-5234-1697Dmitrii Yu. Korshunov7https://orcid.org/0009-0005-9819-0598Yaroslav B. Tsololo8https://orcid.org/0000-0001-7744-0002Vadim V. Usikov9https://orcid.org/0000-0002-7642-4665Andrey V. Polikarpov10North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation Hospital for war veterans, Saint Petersburg, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationFederal Center for Traumatology, Orthopedics and Endoprosthetics, Smolensk, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationNorth-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russian FederationHospital for war veterans, Saint Petersburg, Russian FederationIntroduction Instability of the total hip arthroplasty is a common complication and an indication for revision arthroplasty. The implant instability is diagnosed as aseptic with no microbiological culture growth to be obtained through preoperative synovial aspiration. Etiological interpretation of intraoperative findings in cases of so-called "aseptic instability" is critical for determining subsequent treatment strategies. The objective was to determine the role of microbiological methods in diagnosing periprosthetic joint infection (PJI) of the hip. Material and methods A bacteriological analysis was produced for 173 patients with aseptic instability of total hip replacement. The patients aged 27 to 82 years. Based on laboratory, clinical and microbiological (MB) findings, the patients were divided into two groups. The first group consisted of 118 (68.2 %) patients who underwent one-stage revision and had a favorable postoperative prognosis. The second group consisted of 55 (31.8 %) patients with elevated hematological parameters, local signs of inflammation, positive MB findings and had unfavorable prognosis. These patients underwent two-stage revision arthroplasty. Biopsy samples were tested using polymerase chain reaction (PCR) in cases of minimal microbial load. Results Positive MB results were registered in 5.1 % of patients in the first group and in 25.5 % of patients in the second group. Intraoperative biopsies revealed positive results in 20.3 % of the first group and 30.9 % of the second group. PCR identified PJI in 7.5 % of MB biopsies and in 19.6 % of aspirates. Discussion The findings indicated low diagnostic value of microbiological cultures with PCR improving diagnostic accuracy by 7.5 %. Detection of low-virulence microorganisms including coagulase-negative staphylococci required specific evaluation criteria. Conclusion Microbiological culturing demonstrated moderate sensitivity, in low-virulence infections, in particular, while PCR in low-virulence infections was essential in establishing the microbial etiology of PJI.joint replacementperiprosthetic joint infectioncoagulase-negative staphylococcihip jointjoint instabilitymicrobiological studiespolymerase chain reaction |
| spellingShingle | Stanislav A. Linnik Elena A. Orishak Artem M. Ermakov Ivan O. Kucheev Lyudmila Yu. Nilova Evgenii M. Fadeev Giorgi Karagezov Dmitrii Yu. Korshunov Yaroslav B. Tsololo Vadim V. Usikov Andrey V. Polikarpov The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty Гений oртопедии joint replacement periprosthetic joint infection coagulase-negative staphylococci hip joint joint instability microbiological studies polymerase chain reaction |
| title | The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| title_full | The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| title_fullStr | The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| title_full_unstemmed | The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| title_short | The role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| title_sort | role of microbiological methods in diagnosis of periprosthetic joint infection in patients with aseptic loosening of total hip arthroplasty |
| topic | joint replacement periprosthetic joint infection coagulase-negative staphylococci hip joint joint instability microbiological studies polymerase chain reaction |
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