Role of oral bio-enhanced curcumin in dry eye disease
Purpose: To assess the role of oral bio-enhanced curcumin in dry eye disease (DED). Design: Randomized, double-masked, placebo-controlled clinical study conducted at a tertiary eye center. Methods: Forty patients of bilateral mild to moderate DED were randomized in two groups – group A (topical carb...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1572_24 |
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| Summary: | Purpose:
To assess the role of oral bio-enhanced curcumin in dry eye disease (DED).
Design:
Randomized, double-masked, placebo-controlled clinical study conducted at a tertiary eye center.
Methods:
Forty patients of bilateral mild to moderate DED were randomized in two groups – group A (topical carboxy methyl cellulose QID + oral placebo) and group B (topical carboxy methyl cellulose QID + oral bio-enhanced curcumin). The objective parameters of DED were quantified at baseline and compared at 3 months follow-up.
Results:
At three months follow-up, there was significant improvement in curcumin group in terms of Ocular Surface Disease Index (OSDI) score (P = 0.002), tear meniscus height (TMH) (P = 0.002), tear volume (P = 0.006), tear break-up time (TBUT) (P < 0.001), non-invasive break-up time (NIBUT) (P = 0.026), lipid layer thickness (LLT) (P = 0.01), and decrease in bulbar redness (P = 0.002). There was no significant improvement in limbal redness (P = 0.097), corneal-staining score (P = 0.93), and Schirmer’s test (P = 0.42). Mild adverse drug reaction was observed in three cases of the curcumin group and one case of group A.
Conclusions:
Oral bio-enhanced curcumin is a safe and effective treatment modality in cases of mild to moderate DED. It effectively improves the tear film stability, LLT, and TMH and reduces the bulbar redness. |
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| ISSN: | 0301-4738 1998-3689 |