Lipids dysregulation in diseases: core concepts, targets and treatment strategies
Abstract Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid metabolism is associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. This review exp...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02425-1 |
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| author | Tikam Chand Dakal Feng Xiao Chandra Kanta Bhusal Poorna Chandrika Sabapathy Rakesh Segal Juan Chen Xiaodong Bai |
| author_facet | Tikam Chand Dakal Feng Xiao Chandra Kanta Bhusal Poorna Chandrika Sabapathy Rakesh Segal Juan Chen Xiaodong Bai |
| author_sort | Tikam Chand Dakal |
| collection | DOAJ |
| description | Abstract Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid metabolism is associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. This review explores the mechanisms underlying lipid metabolism, emphasizing the roles of key lipid species such as triglycerides, phospholipids, sphingolipids, and sterols in cellular physiology and pathophysiology. It also examines the genetic and environmental factors contributing to lipid dysregulation and the challenges of diagnosing and managing lipid-related disorders. Recent advancements in lipid-lowering therapies, including PCSK9 inhibitors, ezetimibe, bempedoic acid, and olpasiran, provide promising treatment options. However, these advancements are accompanied by challenges related to cost, accessibility, and patient adherence. The review highlights the need for personalized medicine approaches to address the interplay between genetics and environmental factors in lipid metabolism. As lipidomics and advanced diagnostic tools continue to progress, a deeper understanding of lipid-related disorders could pave the way for more effective therapeutic strategies. |
| format | Article |
| id | doaj-art-7ca242aa022b4148b7f4c353f92fddb0 |
| institution | OA Journals |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-7ca242aa022b4148b7f4c353f92fddb02025-08-20T02:15:02ZengBMCLipids in Health and Disease1476-511X2025-02-0124112110.1186/s12944-024-02425-1Lipids dysregulation in diseases: core concepts, targets and treatment strategiesTikam Chand Dakal0Feng Xiao1Chandra Kanta Bhusal2Poorna Chandrika Sabapathy3Rakesh Segal4Juan Chen5Xiaodong Bai6Genome and Computational Biology Lab, Mohanlal Sukhadia, UniversityDepartment of Gastroenterology, The Second Affiliated Hospital of Shandong First Medical UniversityAarupadai Veedu Medical College and Hospital, VMRF-DUAarupadai Veedu Medical College and Hospital, VMRF-DUAarupadai Veedu Medical College and Hospital, VMRF-DUDepartment of Gastroenterology, The Second Affiliated Hospital of Shandong First Medical UniversityDepartment of Plastic Surgery, Southern University of Science and Technology HospitalAbstract Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid metabolism is associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. This review explores the mechanisms underlying lipid metabolism, emphasizing the roles of key lipid species such as triglycerides, phospholipids, sphingolipids, and sterols in cellular physiology and pathophysiology. It also examines the genetic and environmental factors contributing to lipid dysregulation and the challenges of diagnosing and managing lipid-related disorders. Recent advancements in lipid-lowering therapies, including PCSK9 inhibitors, ezetimibe, bempedoic acid, and olpasiran, provide promising treatment options. However, these advancements are accompanied by challenges related to cost, accessibility, and patient adherence. The review highlights the need for personalized medicine approaches to address the interplay between genetics and environmental factors in lipid metabolism. As lipidomics and advanced diagnostic tools continue to progress, a deeper understanding of lipid-related disorders could pave the way for more effective therapeutic strategies.https://doi.org/10.1186/s12944-024-02425-1Lipid metabolismDyslipidemiaCardiovascular disease (CVD)LipidomicsTriglyceridesPhospholipids |
| spellingShingle | Tikam Chand Dakal Feng Xiao Chandra Kanta Bhusal Poorna Chandrika Sabapathy Rakesh Segal Juan Chen Xiaodong Bai Lipids dysregulation in diseases: core concepts, targets and treatment strategies Lipids in Health and Disease Lipid metabolism Dyslipidemia Cardiovascular disease (CVD) Lipidomics Triglycerides Phospholipids |
| title | Lipids dysregulation in diseases: core concepts, targets and treatment strategies |
| title_full | Lipids dysregulation in diseases: core concepts, targets and treatment strategies |
| title_fullStr | Lipids dysregulation in diseases: core concepts, targets and treatment strategies |
| title_full_unstemmed | Lipids dysregulation in diseases: core concepts, targets and treatment strategies |
| title_short | Lipids dysregulation in diseases: core concepts, targets and treatment strategies |
| title_sort | lipids dysregulation in diseases core concepts targets and treatment strategies |
| topic | Lipid metabolism Dyslipidemia Cardiovascular disease (CVD) Lipidomics Triglycerides Phospholipids |
| url | https://doi.org/10.1186/s12944-024-02425-1 |
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