Characterization and treatment of brain metastases from pancreatic cancer: a systematic review
Abstract Background Brain metastases (BM) from pancreatic cancer have low incidence, carry a poor prognosis, and have limited treatment options. Summarizing disease features and treatment protocols can help understand and improve prognosis. Methods Registered with INPLASY and following PRISMA guidel...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02623-y |
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| author | Yuanchi Ma Hairong He Boyang Li Weiqi Lyu Weikun Qian Liang Han Zheng Wang Kongyuan Wei |
| author_facet | Yuanchi Ma Hairong He Boyang Li Weiqi Lyu Weikun Qian Liang Han Zheng Wang Kongyuan Wei |
| author_sort | Yuanchi Ma |
| collection | DOAJ |
| description | Abstract Background Brain metastases (BM) from pancreatic cancer have low incidence, carry a poor prognosis, and have limited treatment options. Summarizing disease features and treatment protocols can help understand and improve prognosis. Methods Registered with INPLASY and following PRISMA guidelines, the study searched PubMed, Embase, Scopus, and Web of Science from database inception to 9th January 2025. The Kaplan–Meier method was used to calculate the median survival time and interquartile range (IQR) of Overall Survival (OS), and the corresponding plot was drawn. Results A total of 614 patients with BM from pancreatic cancer were included, originating from 24 case reports & series and 3 retrospective cohort studies. BM was usually multiple (n = 32, 71.1%), and mostly affecting frontal lobes (n = 30, 23.8%). Radiotherapy was primary treatment for BM in both pancreatic surgical (n = 44, 72.1%) and non-surgical (n = 8, 66.7%) groups, and most patients in the non-surgical group underwent chemotherapy and targeted therapy (41.7% vs 6.6%). Patients who underwent pancreatic surgery, had longer time from diagnosis of pancreatic cancer to BM (median: 24.0 vs 11.9 months) but shorter post-BM survival [median: 6.0 (case report/series), 3.0 (retrospective cohort study) vs 10.0 months]. Conclusion This review covers the characteristics, treatment, and prognosis of patients with BM from pancreatic cancer. Radiotherapy may be considered the primary treatment for BM, and pancreatic surgery may impact treatment and prognosis. Large multicenter studies are needed in view of low BM incidence from pancreatic cancer. |
| format | Article |
| id | doaj-art-7ca0da4d313c409fbc881ade3fcbeabf |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-7ca0da4d313c409fbc881ade3fcbeabf2025-08-20T03:46:28ZengSpringerDiscover Oncology2730-60112025-07-0116111810.1007/s12672-025-02623-yCharacterization and treatment of brain metastases from pancreatic cancer: a systematic reviewYuanchi Ma0Hairong He1Boyang Li2Weiqi Lyu3Weikun Qian4Liang Han5Zheng Wang6Kongyuan Wei7Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background Brain metastases (BM) from pancreatic cancer have low incidence, carry a poor prognosis, and have limited treatment options. Summarizing disease features and treatment protocols can help understand and improve prognosis. Methods Registered with INPLASY and following PRISMA guidelines, the study searched PubMed, Embase, Scopus, and Web of Science from database inception to 9th January 2025. The Kaplan–Meier method was used to calculate the median survival time and interquartile range (IQR) of Overall Survival (OS), and the corresponding plot was drawn. Results A total of 614 patients with BM from pancreatic cancer were included, originating from 24 case reports & series and 3 retrospective cohort studies. BM was usually multiple (n = 32, 71.1%), and mostly affecting frontal lobes (n = 30, 23.8%). Radiotherapy was primary treatment for BM in both pancreatic surgical (n = 44, 72.1%) and non-surgical (n = 8, 66.7%) groups, and most patients in the non-surgical group underwent chemotherapy and targeted therapy (41.7% vs 6.6%). Patients who underwent pancreatic surgery, had longer time from diagnosis of pancreatic cancer to BM (median: 24.0 vs 11.9 months) but shorter post-BM survival [median: 6.0 (case report/series), 3.0 (retrospective cohort study) vs 10.0 months]. Conclusion This review covers the characteristics, treatment, and prognosis of patients with BM from pancreatic cancer. Radiotherapy may be considered the primary treatment for BM, and pancreatic surgery may impact treatment and prognosis. Large multicenter studies are needed in view of low BM incidence from pancreatic cancer.https://doi.org/10.1007/s12672-025-02623-yPancreatic cancerBrain metastasisPancreatic cancer surgeryTreatmentPrognosis |
| spellingShingle | Yuanchi Ma Hairong He Boyang Li Weiqi Lyu Weikun Qian Liang Han Zheng Wang Kongyuan Wei Characterization and treatment of brain metastases from pancreatic cancer: a systematic review Discover Oncology Pancreatic cancer Brain metastasis Pancreatic cancer surgery Treatment Prognosis |
| title | Characterization and treatment of brain metastases from pancreatic cancer: a systematic review |
| title_full | Characterization and treatment of brain metastases from pancreatic cancer: a systematic review |
| title_fullStr | Characterization and treatment of brain metastases from pancreatic cancer: a systematic review |
| title_full_unstemmed | Characterization and treatment of brain metastases from pancreatic cancer: a systematic review |
| title_short | Characterization and treatment of brain metastases from pancreatic cancer: a systematic review |
| title_sort | characterization and treatment of brain metastases from pancreatic cancer a systematic review |
| topic | Pancreatic cancer Brain metastasis Pancreatic cancer surgery Treatment Prognosis |
| url | https://doi.org/10.1007/s12672-025-02623-y |
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