Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex
The objective: to study drug susceptibility of M. avium and M. intracellulare isolates received from patients with mycobacteriosis residing in the North Western Federal District using the Sensititre SLOMYCO panels.Subjects and Methods. From 2014 to 2020, 192 slow-growing MAC strains (164 – M. avium,...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2022-12-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1691 |
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| author | D. A. Starkova V. Yu. Zhuravlev N. S. Solovieva |
| author_facet | D. A. Starkova V. Yu. Zhuravlev N. S. Solovieva |
| author_sort | D. A. Starkova |
| collection | DOAJ |
| description | The objective: to study drug susceptibility of M. avium and M. intracellulare isolates received from patients with mycobacteriosis residing in the North Western Federal District using the Sensititre SLOMYCO panels.Subjects and Methods. From 2014 to 2020, 192 slow-growing MAC strains (164 – M. avium, 28 – M. intracellulare) obtained from HIV-negative patients with pulmonary mycobacteriosis were studied. Drug susceptibility testing of MAC strains was performed using the Sensititre SLOMYCO panel consisting of 13 antibacterial drugs.Results. Of the 13 antibacterial drugs, clarithromycin was also most effective against both M. avium (67.1%; 110/164) and M. intracellulare (60.7%; 17/28) (p > 0.05). The proportion of M. avium and M. intracellulare strains sensitive to linezolid was high and amounted to 57.3 and 53.5%, as well as to amikacin – 57.3 and 53.5% respectively.Of the four antibacterial drugs of the Sensititre SLOMYCO panel (clarithromycin, moxifloxacin, linezolid, and amikacin), for which critical concentrations (CC) were established, clarithromycin was the most effective against M. avium and M. intracellulare. Antibiotic-resistant M. avium isolates were more frequent in the group of previously treated patients. |
| format | Article |
| id | doaj-art-7c9d8517d93f4a088f0c5d8941df6fe4 |
| institution | DOAJ |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-7c9d8517d93f4a088f0c5d8941df6fe42025-08-20T03:02:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062022-12-0110011394710.21292/2075-1230-2022-100-11-39-471686Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complexD. A. Starkova0V. Yu. Zhuravlev1N. S. Solovieva2Paster St. Petersburg Research Institute of Epidemiology and MicrobiologySt. Petersburg Phthisiopulmonology Research InstituteSt. Petersburg Phthisiopulmonology Research Institute,The objective: to study drug susceptibility of M. avium and M. intracellulare isolates received from patients with mycobacteriosis residing in the North Western Federal District using the Sensititre SLOMYCO panels.Subjects and Methods. From 2014 to 2020, 192 slow-growing MAC strains (164 – M. avium, 28 – M. intracellulare) obtained from HIV-negative patients with pulmonary mycobacteriosis were studied. Drug susceptibility testing of MAC strains was performed using the Sensititre SLOMYCO panel consisting of 13 antibacterial drugs.Results. Of the 13 antibacterial drugs, clarithromycin was also most effective against both M. avium (67.1%; 110/164) and M. intracellulare (60.7%; 17/28) (p > 0.05). The proportion of M. avium and M. intracellulare strains sensitive to linezolid was high and amounted to 57.3 and 53.5%, as well as to amikacin – 57.3 and 53.5% respectively.Of the four antibacterial drugs of the Sensititre SLOMYCO panel (clarithromycin, moxifloxacin, linezolid, and amikacin), for which critical concentrations (CC) were established, clarithromycin was the most effective against M. avium and M. intracellulare. Antibiotic-resistant M. avium isolates were more frequent in the group of previously treated patients.https://www.tibl-journal.com/jour/article/view/1691mycobacteriosis<i>mycobacterium aviumm. intracellulare</i>drug susceptibilitysensititre slomycominimum inhibitory concentrationantibacterial drugs |
| spellingShingle | D. A. Starkova V. Yu. Zhuravlev N. S. Solovieva Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex Туберкулез и болезни лёгких mycobacteriosis <i>mycobacterium avium m. intracellulare</i> drug susceptibility sensititre slomyco minimum inhibitory concentration antibacterial drugs |
| title | Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex |
| title_full | Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex |
| title_fullStr | Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex |
| title_full_unstemmed | Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex |
| title_short | Drug susceptibility of clinical isolates of <i>Mycobacterium avium</i> complex |
| title_sort | drug susceptibility of clinical isolates of i mycobacterium avium i complex |
| topic | mycobacteriosis <i>mycobacterium avium m. intracellulare</i> drug susceptibility sensititre slomyco minimum inhibitory concentration antibacterial drugs |
| url | https://www.tibl-journal.com/jour/article/view/1691 |
| work_keys_str_mv | AT dastarkova drugsusceptibilityofclinicalisolatesofimycobacteriumaviumicomplex AT vyuzhuravlev drugsusceptibilityofclinicalisolatesofimycobacteriumaviumicomplex AT nssolovieva drugsusceptibilityofclinicalisolatesofimycobacteriumaviumicomplex |