Efficacy and safety of a novel short course rifapentine and isoniazid regimen for the preventive treatment of tuberculosis in Chinese silicosis patients: a pilot study (SCRIPT-TB)

Efficacy and safety of a novel short course rifapentine and isoniazid regimen for the preventive treatment of tuberculosis in Chinese silicosis patients: a pilot study (SCRIPT-TB)

Background: Tuberculosis preventive treatment (TPT) is essential for the end TB Strategy, but shorter and better tolerated regimens are needed to boost its coverage and acceptance.Methods: Silicosis patients aged 18 to 65 years received a novel 1H3P3 regimen (400 mg isoniazid and 450 mg rifapentine,...

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Bibliographic Details
Main Authors: Qiao-Ling Ruan, Qing-Luan Yang, Chun-Lian Ma, Miao-Yao Lin, Xi-Tian Huang, Ya-Pin Mao, Ji-Mei Gao, Jin-Ju Li, Xia-Ning Zhang, Zhi-Xiang You, Quan-Qing Zheng, Yan-Fei Ren, Xue-Feng Liu, Ling-Yun Shao, Wen-Hong Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Controlled clinical trial
tuberculosis
preventive treatment
rifapentine
isoniazid
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2502010
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