Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population
Carcinoma esophagus is a common malignancy of the Indian subcontinent. The role of positron-emission tomography–computed tomography (PET-CT) in the assessment of response to radiotherapy has been widely studied and accepted. However, its precise use as a predictive tool for actual histopathological...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-10-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_114_18 |
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| author | Sankalp Singh Niharika Bisht Arti Sarin A. V. S. Kumar Samir Gupta Amul Kapoor Prabha Mishra |
| author_facet | Sankalp Singh Niharika Bisht Arti Sarin A. V. S. Kumar Samir Gupta Amul Kapoor Prabha Mishra |
| author_sort | Sankalp Singh |
| collection | DOAJ |
| description | Carcinoma esophagus is a common malignancy of the Indian subcontinent. The role of positron-emission tomography–computed tomography (PET-CT) in the assessment of response to radiotherapy has been widely studied and accepted. However, its precise use as a predictive tool for actual histopathological response to radiotherapy needs further evaluation, especially in an Indian population. The aim of this study was to identify a quantum of metabolic response on PET-CT that can also predict for a good pathological response. Forty-four patients of carcinoma esophagus treated with neoadjuvant chemoradiotherapy followed by surgery were included in the study. All patients underwent a PET-CT before starting treatment as well as at 4–6 weeks after completion of radiotherapy. The percentage change in pre and posttreatment maximum standardized uptake value (SUVmax) value (ΔSUV%) of the primary tumor was correlated against histopathological tumor regression grade (TRG) as per the Mandard's system. Seventy-five percent of the patients with a significant metabolic response, i.e., a ΔSUV% of 60% or more, also had a good pathological response to treatment. Thus, by considering a ΔSUV% of 60%, we could predict for a good pathological response (TRG of 1 or 2) to chemoradiotherapy in our patient set with a sensitivity of 95.45% and a specificity of 72.72%. |
| format | Article |
| id | doaj-art-7c948233fe0e48248b4feca550ceec4d |
| institution | Kabale University |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-7c948233fe0e48248b4feca550ceec4d2025-08-20T03:48:36ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122019-10-01180436136510.4103/wjnm.WJNM_114_18Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian populationSankalp Singh0Niharika Bisht1Arti Sarin2A. V. S. Kumar3Samir Gupta4Amul Kapoor5Prabha Mishra6Department of Radiation Oncology, Command Hospital (CC), Lucknow, Uttar Pradesh, IndiaDepartment of Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, IndiaDepartment of Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, IndiaDepartment of Nuclear Medicine, Command Hospital (SC), Pune, Maharashtra, IndiaDepartment of Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, IndiaDepartment of Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, IndiaDepartment of Pathology, Command Hospital (SC), Pune, Maharashtra, IndiaCarcinoma esophagus is a common malignancy of the Indian subcontinent. The role of positron-emission tomography–computed tomography (PET-CT) in the assessment of response to radiotherapy has been widely studied and accepted. However, its precise use as a predictive tool for actual histopathological response to radiotherapy needs further evaluation, especially in an Indian population. The aim of this study was to identify a quantum of metabolic response on PET-CT that can also predict for a good pathological response. Forty-four patients of carcinoma esophagus treated with neoadjuvant chemoradiotherapy followed by surgery were included in the study. All patients underwent a PET-CT before starting treatment as well as at 4–6 weeks after completion of radiotherapy. The percentage change in pre and posttreatment maximum standardized uptake value (SUVmax) value (ΔSUV%) of the primary tumor was correlated against histopathological tumor regression grade (TRG) as per the Mandard's system. Seventy-five percent of the patients with a significant metabolic response, i.e., a ΔSUV% of 60% or more, also had a good pathological response to treatment. Thus, by considering a ΔSUV% of 60%, we could predict for a good pathological response (TRG of 1 or 2) to chemoradiotherapy in our patient set with a sensitivity of 95.45% and a specificity of 72.72%.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_114_18carcinoma esophaguspositron-emission tomography–computed tomographyradiotherapy |
| spellingShingle | Sankalp Singh Niharika Bisht Arti Sarin A. V. S. Kumar Samir Gupta Amul Kapoor Prabha Mishra Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population World Journal of Nuclear Medicine carcinoma esophagus positron-emission tomography–computed tomography radiotherapy |
| title | Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population |
| title_full | Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population |
| title_fullStr | Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population |
| title_full_unstemmed | Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population |
| title_short | Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population |
| title_sort | using positron emission tomography computed tomography for predicting radiotherapy induced tumor regression in carcinoma esophagus in an indian population |
| topic | carcinoma esophagus positron-emission tomography–computed tomography radiotherapy |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_114_18 |
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