High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model. Drosophila primary neurons offer a sensitive readout for neurotoxicty, as their neurites develop dysmorphic features in...

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Bibliographic Details
Main Authors: Joost Schulte, Katharine J Sepp, Chaohong Wu, Pengyu Hong, J Troy Littleton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0023841
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