Angiotensinogen and C3 compete for renin-induced complement activation

Angiotensinogen and C3 compete for renin-induced complement activation

Renin from plasma, kidney, and recombinant sources was previously demonstrated to cleave C3 to C3a and C3b. C3a was generated at a similar rate to that by C3 convertase, and C3 cleavage was inhibited by the renin inhibitor aliskiren. Renin endogenously produced by Calu6 cells also led to C3 depositi...

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Bibliographic Details
Main Authors: Ann-Charlotte Kristoffersson, Albin Sköld, Charlotte Welinder, Markus Wendler, Gabriella Kalliokoski, Zivile Bekassy, Diana Karpman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
C3
complement
renin
angiotensinogen
kidney
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563868/full
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