Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2009/729057 |
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| _version_ | 1849409529574326272 |
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| author | Yoshifumi Murata Youko Kodama Takashi Isobe Kyoko Kofuji Susumu Kawashima |
| author_facet | Yoshifumi Murata Youko Kodama Takashi Isobe Kyoko Kofuji Susumu Kawashima |
| author_sort | Yoshifumi Murata |
| collection | DOAJ |
| description | Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix. The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate. In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water. |
| format | Article |
| id | doaj-art-7c879eec95fe4e989efe27eb755f3b14 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-7c879eec95fe4e989efe27eb755f3b142025-08-20T03:35:28ZengWileyInternational Journal of Polymer Science1687-94221687-94302009-01-01200910.1155/2009/729057729057Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel BeadsYoshifumi Murata0Youko Kodama1Takashi Isobe2Kyoko Kofuji3Susumu Kawashima4Faculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanCalcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix. The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate. In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water.http://dx.doi.org/10.1155/2009/729057 |
| spellingShingle | Yoshifumi Murata Youko Kodama Takashi Isobe Kyoko Kofuji Susumu Kawashima Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads International Journal of Polymer Science |
| title | Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads |
| title_full | Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads |
| title_fullStr | Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads |
| title_full_unstemmed | Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads |
| title_short | Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads |
| title_sort | drug release profile from calcium induced alginate phosphate composite gel beads |
| url | http://dx.doi.org/10.1155/2009/729057 |
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