Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applica...
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2013-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0071345 |
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| author | Tina Shah Jorgen Engmann Caroline Dale Sonia Shah Jon White Claudia Giambartolomei Stela McLachlan Delilah Zabaneh Alana Cavadino Chris Finan Andrew Wong Antoinette Amuzu Ken Ong Tom Gaunt Michael V Holmes Helen Warren Daniel I Swerdlow Teri-Louise Davies Fotios Drenos Jackie Cooper Reecha Sofat Mark Caulfield Shah Ebrahim Debbie A Lawlor Philippa J Talmud Steve E Humphries Christine Power Elina Hypponen Marcus Richards Rebecca Hardy Diana Kuh Nicholas Wareham Claudia Langenberg Yoav Ben-Shlomo Ian N Day Peter Whincup Richard Morris Mark W J Strachan Jacqueline Price Meena Kumari Meena Kumari Mika Kivimaki Vincent Plagnol Frank Dudbridge John C Whittaker Juan P Casas Aroon D Hingorani UCLEB Consortium |
| author_facet | Tina Shah Jorgen Engmann Caroline Dale Sonia Shah Jon White Claudia Giambartolomei Stela McLachlan Delilah Zabaneh Alana Cavadino Chris Finan Andrew Wong Antoinette Amuzu Ken Ong Tom Gaunt Michael V Holmes Helen Warren Daniel I Swerdlow Teri-Louise Davies Fotios Drenos Jackie Cooper Reecha Sofat Mark Caulfield Shah Ebrahim Debbie A Lawlor Philippa J Talmud Steve E Humphries Christine Power Elina Hypponen Marcus Richards Rebecca Hardy Diana Kuh Nicholas Wareham Claudia Langenberg Yoav Ben-Shlomo Ian N Day Peter Whincup Richard Morris Mark W J Strachan Jacqueline Price Meena Kumari Meena Kumari Mika Kivimaki Vincent Plagnol Frank Dudbridge John C Whittaker Juan P Casas Aroon D Hingorani UCLEB Consortium |
| author_sort | Tina Shah |
| collection | DOAJ |
| description | Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies. |
| format | Article |
| id | doaj-art-7c7b63b1f59a43a7b092f3deed11c53b |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7c7b63b1f59a43a7b092f3deed11c53b2025-08-20T03:10:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7134510.1371/journal.pone.0071345Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.Tina ShahJorgen EngmannCaroline DaleSonia ShahJon WhiteClaudia GiambartolomeiStela McLachlanDelilah ZabanehAlana CavadinoChris FinanAndrew WongAntoinette AmuzuKen OngTom GauntMichael V HolmesHelen WarrenDaniel I SwerdlowTeri-Louise DaviesFotios DrenosJackie CooperReecha SofatMark CaulfieldShah EbrahimDebbie A LawlorPhilippa J TalmudSteve E HumphriesChristine PowerElina HypponenMarcus RichardsRebecca HardyDiana KuhNicholas WarehamClaudia LangenbergYoav Ben-ShlomoIan N DayPeter WhincupRichard MorrisMark W J StrachanJacqueline PriceMeena KumariMeena KumariMika KivimakiVincent PlagnolFrank DudbridgeJohn C WhittakerJuan P CasasAroon D HingoraniUCLEB ConsortiumSubstantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.https://doi.org/10.1371/journal.pone.0071345 |
| spellingShingle | Tina Shah Jorgen Engmann Caroline Dale Sonia Shah Jon White Claudia Giambartolomei Stela McLachlan Delilah Zabaneh Alana Cavadino Chris Finan Andrew Wong Antoinette Amuzu Ken Ong Tom Gaunt Michael V Holmes Helen Warren Daniel I Swerdlow Teri-Louise Davies Fotios Drenos Jackie Cooper Reecha Sofat Mark Caulfield Shah Ebrahim Debbie A Lawlor Philippa J Talmud Steve E Humphries Christine Power Elina Hypponen Marcus Richards Rebecca Hardy Diana Kuh Nicholas Wareham Claudia Langenberg Yoav Ben-Shlomo Ian N Day Peter Whincup Richard Morris Mark W J Strachan Jacqueline Price Meena Kumari Meena Kumari Mika Kivimaki Vincent Plagnol Frank Dudbridge John C Whittaker Juan P Casas Aroon D Hingorani UCLEB Consortium Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS ONE |
| title | Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. |
| title_full | Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. |
| title_fullStr | Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. |
| title_full_unstemmed | Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. |
| title_short | Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. |
| title_sort | population genomics of cardiometabolic traits design of the university college london london school of hygiene and tropical medicine edinburgh bristol ucleb consortium |
| url | https://doi.org/10.1371/journal.pone.0071345 |
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