A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

Summary: The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after rec...

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Bibliographic Details
Main Authors: Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang, Yunjian Li, Yi Sun, Rongrong Qin, Hualong Feng, Lin Hu, Xuanyi Chen, Maosheng Lu, Xueyan Huang, Haibo Wang, Liwei Jiang, Teng Zuo
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007351
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