Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease

Prenatal and progressive coenzyme Q10 administration to mitigate muscle dysfunction in mitochondrial disease

Abstract Background ADCK genes encode aarF domain‐containing mitochondrial kinases involved in coenzyme Q (CoQ) biosynthesis and regulation. Haploinsufficiency of ADCK2 in humans leads to adult‐onset physical incapacity with reduced mitochondrial CoQ levels in skeletal muscle, resulting in mitochond...

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Bibliographic Details
Main Authors: Juan Diego Hernández‐Camacho, Cristina Vicente‐García, Lorena Ardila‐García, Ana Padilla‐Campos, Guillermo López‐Lluch, Carlos Santos‐Ocaña, Peter S. Zammit, Jaime J. Carvajal, Plácido Navas, Daniel J.M. Fernández‐Ayala
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
ageing
coenzyme Q
development
mitochondria
satellite cell
skeletal muscle
Online Access:https://doi.org/10.1002/jcsm.13574
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