Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study
Summary: The real-world application of tracers for axillary sentinel lymph node biopsy (SLNB) for breast cancer (BC) after neoadjuvant chemotherapy (NAC) in China was unknown. We analyzed the use of individual tracers or combinations and number of SLNs in patients with BC who underwent SLNB with or...
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Elsevier
2025-07-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225011502 |
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| author | Fengjiang Qu Tinghan Jiang Zhenzhen Liu Rui Ling Yi Zhao Hongjian Yang Yunjiang Liu Ke Liu Jianguo Zhang Dahua Mao Jianjun He Zhigang Yu Yinhua Liu Peifen Fu Jiandong Wang Hongchuan Jiang Zuowei Zhao Xingsong Tian Zhongwei Cao Kejin Wu Ailin Song Feng Jin Di Wu Zhimin Fan |
| author_facet | Fengjiang Qu Tinghan Jiang Zhenzhen Liu Rui Ling Yi Zhao Hongjian Yang Yunjiang Liu Ke Liu Jianguo Zhang Dahua Mao Jianjun He Zhigang Yu Yinhua Liu Peifen Fu Jiandong Wang Hongchuan Jiang Zuowei Zhao Xingsong Tian Zhongwei Cao Kejin Wu Ailin Song Feng Jin Di Wu Zhimin Fan |
| author_sort | Fengjiang Qu |
| collection | DOAJ |
| description | Summary: The real-world application of tracers for axillary sentinel lymph node biopsy (SLNB) for breast cancer (BC) after neoadjuvant chemotherapy (NAC) in China was unknown. We analyzed the use of individual tracers or combinations and number of SLNs in patients with BC who underwent SLNB with or without axillary lymph node dissection (ALND) after NAC in 20 hospitals in ten years. A total of 1251 BC patients underwent SLNB or SLNB + ALND after NAC, including 853 (68.2%, 853/1251) with a single tracer, predominantly Methylene blue (MB) (60.1%, 752/1251); and 398 (31.8%, 398/1251) with dual tracers, mainly MB combined with radioisotope (RI) (18.1%, 226/1251).The results showed that the predominance of the MB single-tracer method for SLNB after NAC limits the popularity of SLNB in patients with BC after NAC in China. MB combined with RI is the main dual-tracer method, and detects SLNs more effectively than MB alone. |
| format | Article |
| id | doaj-art-7c6f6443224147d3bdcc1572f3bb5a26 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7c6f6443224147d3bdcc1572f3bb5a262025-08-20T03:29:31ZengElsevieriScience2589-00422025-07-0128711288910.1016/j.isci.2025.112889Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world studyFengjiang Qu0Tinghan Jiang1Zhenzhen Liu2Rui Ling3Yi Zhao4Hongjian Yang5Yunjiang Liu6Ke Liu7Jianguo Zhang8Dahua Mao9Jianjun He10Zhigang Yu11Yinhua Liu12Peifen Fu13Jiandong Wang14Hongchuan Jiang15Zuowei Zhao16Xingsong Tian17Zhongwei Cao18Kejin Wu19Ailin Song20Feng Jin21Di Wu22Zhimin Fan23Department of Emergency Surgery, The First Hospital of Jilin University, Changchun, Jilin Province 130021, ChinaMinistry of Education, The First Hospital of Jilin University, Changchun, Jilin Province 130021, ChinaDepartment of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan Province 450008, ChinaDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, ChinaSurgical Oncology Department, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, ChinaDepartment of Breast Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province 310022, ChinaDepartment of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaFourth Department of Breast Surgery, Jilin Cancer Hospital, Changchun, Jilin Province, ChinaDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150086, ChinaDepartment of Breast Surgery, Affiliated Wudang Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550009, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710061, ChinaDepartment of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250033, ChinaBreast Disease Center, Peking University First Hospital, Beijing 100034, ChinaDepartment of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, ChinaDepartment of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100852, ChinaDepartment of Breast Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116023, ChinaDepartment of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, ChinaDepartment of Thyroid, Breast, Hernia Surgery, The Inner Mongolia Autonomous Region People’s Hospital, Hohhot, Inner Mongolia Autonomous Region 010017, ChinaDepartment of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730000, ChinaDepartment of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, ChinaDepartment of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China; Corresponding authorDepartment of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China; Corresponding authorSummary: The real-world application of tracers for axillary sentinel lymph node biopsy (SLNB) for breast cancer (BC) after neoadjuvant chemotherapy (NAC) in China was unknown. We analyzed the use of individual tracers or combinations and number of SLNs in patients with BC who underwent SLNB with or without axillary lymph node dissection (ALND) after NAC in 20 hospitals in ten years. A total of 1251 BC patients underwent SLNB or SLNB + ALND after NAC, including 853 (68.2%, 853/1251) with a single tracer, predominantly Methylene blue (MB) (60.1%, 752/1251); and 398 (31.8%, 398/1251) with dual tracers, mainly MB combined with radioisotope (RI) (18.1%, 226/1251).The results showed that the predominance of the MB single-tracer method for SLNB after NAC limits the popularity of SLNB in patients with BC after NAC in China. MB combined with RI is the main dual-tracer method, and detects SLNs more effectively than MB alone.http://www.sciencedirect.com/science/article/pii/S2589004225011502oncologydiagnosticsdiagnostic procedure |
| spellingShingle | Fengjiang Qu Tinghan Jiang Zhenzhen Liu Rui Ling Yi Zhao Hongjian Yang Yunjiang Liu Ke Liu Jianguo Zhang Dahua Mao Jianjun He Zhigang Yu Yinhua Liu Peifen Fu Jiandong Wang Hongchuan Jiang Zuowei Zhao Xingsong Tian Zhongwei Cao Kejin Wu Ailin Song Feng Jin Di Wu Zhimin Fan Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study iScience oncology diagnostics diagnostic procedure |
| title | Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study |
| title_full | Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study |
| title_fullStr | Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study |
| title_full_unstemmed | Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study |
| title_short | Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study |
| title_sort | application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in china a multicenter real world study |
| topic | oncology diagnostics diagnostic procedure |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225011502 |
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