MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839
MicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma. The goal of this study was to characterize the role of miR-200b in th...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-07-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317719577 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849710402153218048 |
|---|---|
| author | Ben-gang Wang Jun-shuai Li Yong-feng Liu Qian Xu |
| author_facet | Ben-gang Wang Jun-shuai Li Yong-feng Liu Qian Xu |
| author_sort | Ben-gang Wang |
| collection | DOAJ |
| description | MicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma. The goal of this study was to characterize the role of miR-200b in the pathogenesis of hepatocellular carcinoma. We identified miR-200b that was predicted to regulate RhoA and circ_000839. Our data establish that miR-200b is expressed at a relatively low level in hepatocellular carcinoma ( p < 0.001). RhoA and circ_000839 are expressed at a relatively high level in hepatocellular carcinoma ( p < 0.001, respectively). Our mechanistic data indicate that RhoA is a direct target of miR-200b ( p < 0.001), binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines ( p < 0.05). And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839 ( p = 0.012, p = 0.002, respectively), while RhoA was positively correlated with circ_000839 ( p < 0.001). Taken together, our data suggest that miR-200b could mediate RhoA gene and circ_000839 to form endogenous competition. And this is a direction for the association study of miR-200b and RhoA in the future. |
| format | Article |
| id | doaj-art-7c6cfa0c6791469799248e933de7d8a8 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-7c6cfa0c6791469799248e933de7d8a82025-08-20T03:14:54ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317719577MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839Ben-gang Wang0Jun-shuai Li1Yong-feng Liu2Qian Xu3Hepatobiliary Surgery Department of General Surgery Institute, The First Affiliated Hospital of China Medical University, Shenyang, ChinaHepatobiliary Surgery Department of General Surgery Institute, The First Affiliated Hospital of China Medical University, Shenyang, ChinaHepatobiliary Surgery Department of General Surgery Institute, The First Affiliated Hospital of China Medical University, Shenyang, ChinaTumor Etiology and Screening Department of General Surgery Institute, The First Affiliated Hospital of China Medical University, Shenyang, ChinaMicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma. The goal of this study was to characterize the role of miR-200b in the pathogenesis of hepatocellular carcinoma. We identified miR-200b that was predicted to regulate RhoA and circ_000839. Our data establish that miR-200b is expressed at a relatively low level in hepatocellular carcinoma ( p < 0.001). RhoA and circ_000839 are expressed at a relatively high level in hepatocellular carcinoma ( p < 0.001, respectively). Our mechanistic data indicate that RhoA is a direct target of miR-200b ( p < 0.001), binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines ( p < 0.05). And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839 ( p = 0.012, p = 0.002, respectively), while RhoA was positively correlated with circ_000839 ( p < 0.001). Taken together, our data suggest that miR-200b could mediate RhoA gene and circ_000839 to form endogenous competition. And this is a direction for the association study of miR-200b and RhoA in the future.https://doi.org/10.1177/1010428317719577 |
| spellingShingle | Ben-gang Wang Jun-shuai Li Yong-feng Liu Qian Xu MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 Tumor Biology |
| title | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
| title_full | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
| title_fullStr | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
| title_full_unstemmed | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
| title_short | MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 |
| title_sort | microrna 200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating rhoa and circrna 000839 |
| url | https://doi.org/10.1177/1010428317719577 |
| work_keys_str_mv | AT bengangwang microrna200bsuppressestheinvasionandmigrationofhepatocellularcarcinomabydownregulatingrhoaandcircrna000839 AT junshuaili microrna200bsuppressestheinvasionandmigrationofhepatocellularcarcinomabydownregulatingrhoaandcircrna000839 AT yongfengliu microrna200bsuppressestheinvasionandmigrationofhepatocellularcarcinomabydownregulatingrhoaandcircrna000839 AT qianxu microrna200bsuppressestheinvasionandmigrationofhepatocellularcarcinomabydownregulatingrhoaandcircrna000839 |