Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract
Urothelial carcinomas of the upper urinary tract (UTUC) are relatively rare and challenging to treat. We present a case report of a 55-year-old male patient with high-grade renal UTUC who received adjuvant pembrolizumab immunotherapy. The patient developed retroperitoneal fibrosis as an immune-relat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Urology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442025001767 |
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| author | L. Gallardo Zamora F.C. von Rundstedt C. Wach W.P. Fendler I. Maric K. Herrmann J.T. Siveke P.F.-Y. Cheung V. Grünwald |
| author_facet | L. Gallardo Zamora F.C. von Rundstedt C. Wach W.P. Fendler I. Maric K. Herrmann J.T. Siveke P.F.-Y. Cheung V. Grünwald |
| author_sort | L. Gallardo Zamora |
| collection | DOAJ |
| description | Urothelial carcinomas of the upper urinary tract (UTUC) are relatively rare and challenging to treat. We present a case report of a 55-year-old male patient with high-grade renal UTUC who received adjuvant pembrolizumab immunotherapy. The patient developed retroperitoneal fibrosis as an immune-related adverse event (irAE) following treatment.To better understand the extent of fibrosis, we utilized 68Ga FAPI-46 PET/CT imaging, a radioligand that binds to fibroblast activation protein alpha expressed on activated fibroblasts. The imaging pattern correlated with histopathological findings of fibrotic tissue.This case highlights the limited experience with rare irAEs due to checkpoint inhibitors, such as retroperitoneal fibrosis. |
| format | Article |
| id | doaj-art-7c5f91be12314b8bb49bc85d42ddd67f |
| institution | Kabale University |
| issn | 2214-4420 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj-art-7c5f91be12314b8bb49bc85d42ddd67f2025-08-20T03:56:45ZengElsevierUrology Case Reports2214-44202025-07-016110310510.1016/j.eucr.2025.103105Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tractL. Gallardo Zamora0F.C. von Rundstedt1C. Wach2W.P. Fendler3I. Maric4K. Herrmann5J.T. Siveke6P.F.-Y. Cheung7V. Grünwald8Universitätsklinikum Wuppertal, Wuppertal, Germany; Corresponding author. Department of Urology, Helios University Hospital Wuppertal, Witten/Herdecke University, Heusnerstrasse 40, 42283, Wuppertal, Germany.Universitätsklinikum Wuppertal, Wuppertal, GermanyUniversitätsklinikum Wuppertal, Wuppertal, GermanyUniversitätsklinikum Essen, Essen, GermanyUniversitätsklinikum Essen, Essen, GermanyUniversitätsklinikum Essen, Essen, GermanyUniversitätsklinikum Essen, Essen, GermanyUniversitätsklinikum Essen, Essen, GermanyUniversitätsklinikum Essen, Essen, GermanyUrothelial carcinomas of the upper urinary tract (UTUC) are relatively rare and challenging to treat. We present a case report of a 55-year-old male patient with high-grade renal UTUC who received adjuvant pembrolizumab immunotherapy. The patient developed retroperitoneal fibrosis as an immune-related adverse event (irAE) following treatment.To better understand the extent of fibrosis, we utilized 68Ga FAPI-46 PET/CT imaging, a radioligand that binds to fibroblast activation protein alpha expressed on activated fibroblasts. The imaging pattern correlated with histopathological findings of fibrotic tissue.This case highlights the limited experience with rare irAEs due to checkpoint inhibitors, such as retroperitoneal fibrosis.http://www.sciencedirect.com/science/article/pii/S2214442025001767Urothelial carcinomaUpper urinary tractRetroperitoneal fibrosisImmune-related adverse eventPembrolizumab68Ga FAPI-46 PET/CT |
| spellingShingle | L. Gallardo Zamora F.C. von Rundstedt C. Wach W.P. Fendler I. Maric K. Herrmann J.T. Siveke P.F.-Y. Cheung V. Grünwald Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract Urology Case Reports Urothelial carcinoma Upper urinary tract Retroperitoneal fibrosis Immune-related adverse event Pembrolizumab 68Ga FAPI-46 PET/CT |
| title | Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| title_full | Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| title_fullStr | Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| title_full_unstemmed | Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| title_short | Fibroblast-directed PET imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| title_sort | fibroblast directed pet imaging reveals a case of retroperitoneal fibrosis after immunotherapy for metastatic urothelial cancer of the upper tract |
| topic | Urothelial carcinoma Upper urinary tract Retroperitoneal fibrosis Immune-related adverse event Pembrolizumab 68Ga FAPI-46 PET/CT |
| url | http://www.sciencedirect.com/science/article/pii/S2214442025001767 |
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