Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance
We present a case of a 79-year-old male who presented with retroperitoneal hematoma a week after motor vehicle accident. Prior history and family history of bleeding were nonsignificant. His activated partial thromboplastin time was found to be prolonged in the emergency department. Further workup w...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/9295780 |
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| author | Sijan Basnet Catherine Lin Rashmi Dhital Izza Mir Elan Mohanty Biswaraj Tharu Sushil Ghimire Dilli Ram Poudel |
| author_facet | Sijan Basnet Catherine Lin Rashmi Dhital Izza Mir Elan Mohanty Biswaraj Tharu Sushil Ghimire Dilli Ram Poudel |
| author_sort | Sijan Basnet |
| collection | DOAJ |
| description | We present a case of a 79-year-old male who presented with retroperitoneal hematoma a week after motor vehicle accident. Prior history and family history of bleeding were nonsignificant. His activated partial thromboplastin time was found to be prolonged in the emergency department. Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF:ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand disease. Immunofluorescence to find an underlying etiology was suggestive of MGUS. Management of AvWD depends on controlling active bleeding and treating the underlying cause. He was treated with factor VIII, haemate-p, rituximab, two cycles of IVIg, and three weeks of oral steroids. |
| format | Article |
| id | doaj-art-7c5cc5f7334f4dd09055ab1847b81962 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-7c5cc5f7334f4dd09055ab1847b819622025-02-03T06:07:49ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/92957809295780Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown SignificanceSijan Basnet0Catherine Lin1Rashmi Dhital2Izza Mir3Elan Mohanty4Biswaraj Tharu5Sushil Ghimire6Dilli Ram Poudel7Department of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USADepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USADepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USADepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USADepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USAMaharajgunj Medical Campus, Tribhuvan University, Kathmandu, NepalDepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USADepartment of Medicine, Reading Hospital, 420 S. Fifth Avenue, West Reading, PA 19611, USAWe present a case of a 79-year-old male who presented with retroperitoneal hematoma a week after motor vehicle accident. Prior history and family history of bleeding were nonsignificant. His activated partial thromboplastin time was found to be prolonged in the emergency department. Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF:ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand disease. Immunofluorescence to find an underlying etiology was suggestive of MGUS. Management of AvWD depends on controlling active bleeding and treating the underlying cause. He was treated with factor VIII, haemate-p, rituximab, two cycles of IVIg, and three weeks of oral steroids.http://dx.doi.org/10.1155/2017/9295780 |
| spellingShingle | Sijan Basnet Catherine Lin Rashmi Dhital Izza Mir Elan Mohanty Biswaraj Tharu Sushil Ghimire Dilli Ram Poudel Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance Case Reports in Oncological Medicine |
| title | Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance |
| title_full | Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance |
| title_fullStr | Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance |
| title_full_unstemmed | Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance |
| title_short | Acquired von Willebrand Disease Associated with Monoclonal Gammopathy of Unknown Significance |
| title_sort | acquired von willebrand disease associated with monoclonal gammopathy of unknown significance |
| url | http://dx.doi.org/10.1155/2017/9295780 |
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