GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons
Dissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.31 |
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| _version_ | 1832550149395578880 |
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| author | H. Golan K. Mikenberg V. Greenberger M. Segal |
| author_facet | H. Golan K. Mikenberg V. Greenberger M. Segal |
| author_sort | H. Golan |
| collection | DOAJ |
| description | Dissociated hippocampal neurons, grown
in culture for 2 to 3 weeks, tended to fire
bursts of synaptic currents at fairly regular
intervals, representing network activity. A
brief exposure of cultured neurons to GABA
caused a total suppression of the spontaneous
network activity. Following a washout of
GABA, the activity was no longer clustered in
bursts and instead, the cells fired at a high
rate tonic manner. The effect of removing
GABA could be seen as long as 1 to 2 days
after GABA withdrawal and is expressed as
an increase in the number of active cells in a
network, as well as in their firing rates. Such
striking effects of GABA removal may
underlie part of the GABA withdrawal
syndrome seen elsewhere. |
| format | Article |
| id | doaj-art-7c5654faa3a04ffdb8004519b981068e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7c5654faa3a04ffdb8004519b981068e2025-02-03T06:07:35ZengWileyNeural Plasticity2090-59041687-54432000-01-0171-2314210.1155/NP.2000.31GABA Withdrawal Modifies Network Activity in Cultured Hippocampal NeuronsH. Golan0K. Mikenberg1V. Greenberger2M. Segal3Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, IsraelDepartment of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, IsraelDissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout of GABA, the activity was no longer clustered in bursts and instead, the cells fired at a high rate tonic manner. The effect of removing GABA could be seen as long as 1 to 2 days after GABA withdrawal and is expressed as an increase in the number of active cells in a network, as well as in their firing rates. Such striking effects of GABA removal may underlie part of the GABA withdrawal syndrome seen elsewhere.http://dx.doi.org/10.1155/NP.2000.31 |
| spellingShingle | H. Golan K. Mikenberg V. Greenberger M. Segal GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons Neural Plasticity |
| title | GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons |
| title_full | GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons |
| title_fullStr | GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons |
| title_full_unstemmed | GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons |
| title_short | GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons |
| title_sort | gaba withdrawal modifies network activity in cultured hippocampal neurons |
| url | http://dx.doi.org/10.1155/NP.2000.31 |
| work_keys_str_mv | AT hgolan gabawithdrawalmodifiesnetworkactivityinculturedhippocampalneurons AT kmikenberg gabawithdrawalmodifiesnetworkactivityinculturedhippocampalneurons AT vgreenberger gabawithdrawalmodifiesnetworkactivityinculturedhippocampalneurons AT msegal gabawithdrawalmodifiesnetworkactivityinculturedhippocampalneurons |