GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons
Dissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.31 |
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| Summary: | Dissociated hippocampal neurons, grown
in culture for 2 to 3 weeks, tended to fire
bursts of synaptic currents at fairly regular
intervals, representing network activity. A
brief exposure of cultured neurons to GABA
caused a total suppression of the spontaneous
network activity. Following a washout of
GABA, the activity was no longer clustered in
bursts and instead, the cells fired at a high
rate tonic manner. The effect of removing
GABA could be seen as long as 1 to 2 days
after GABA withdrawal and is expressed as
an increase in the number of active cells in a
network, as well as in their firing rates. Such
striking effects of GABA removal may
underlie part of the GABA withdrawal
syndrome seen elsewhere. |
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| ISSN: | 2090-5904 1687-5443 |