Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

Many pathogens, including Kaposi's sarcoma herpesvirus (KSHV), lack tractable small animal models. KSHV persists as a multi-copy, nuclear episome in latently infected cells. KSHV latency-associated nuclear antigen (kLANA) binds viral terminal repeat (kTR) DNA to mediate episome persistence. Mod...

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Bibliographic Details
Main Authors: Aline C Habison, Marta Pires de Miranda, Chantal Beauchemin, Min Tan, Sofia A Cerqueira, Bruno Correia, Rajesh Ponnusamy, Edward J Usherwood, Colin E McVey, J Pedro Simas, Kenneth M Kaye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006555&type=printable
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