Biotechnology breakthroughs: Revolutionizing oral cancer treatment
Oral cancer is a global health concern due to its increasing incidence and mortality rates, despite conventional treatments such as surgery, chemotherapy, and radiation therapy. Biotechnology has made significant progress in the management of oral cancer. This essay explores how these advancements a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024002504 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553675934236672 |
|---|---|
| author | Safin Hussein Karzan Qurbani Haider Hamzah Seenaa Ali Sirwan Khalid Ahmed |
| author_facet | Safin Hussein Karzan Qurbani Haider Hamzah Seenaa Ali Sirwan Khalid Ahmed |
| author_sort | Safin Hussein |
| collection | DOAJ |
| description | Oral cancer is a global health concern due to its increasing incidence and mortality rates, despite conventional treatments such as surgery, chemotherapy, and radiation therapy. Biotechnology has made significant progress in the management of oral cancer. This essay explores how these advancements are transforming treatment, offering improved outcomes and enhanced quality of life for patients. Targeted therapies, like cetuximab, disrupt specific pathways in cancer cells, inhibiting their proliferation while minimizing damage to healthy cells. This differs from traditional chemotherapy, which has a nonspecific impact. Immunotherapy, using checkpoint inhibitors like pembrolizumab and nivolumab, enhances the body's immune response against oral cancer cells, particularly in cases resistant to conventional treatment. Gene therapy holds promise in correcting genetic abnormalities that contribute to tumor growth or enhancing the immune system's ability to eradicate cancer cells. Oncolytic viruses and CRISPR-Cas9 are among the tools leading the way in personalized interventions. Liquid biopsies, which analyze circulating tumor cells and biomarkers, provide a non-invasive method for diagnosing and monitoring oral cancer. Integration with advanced bioinformatics and artificial intelligence enables precision medicine tailored to individual tumors. Collectively, these advancements offer hope for transforming oral cancer into a manageable condition. Achieving this goal requires collaborative efforts and continued exploration to optimize treatment effectiveness and elevate patient survival rates. |
| format | Article |
| id | doaj-art-7c556cf5c6dd49e494507630ed60e2d6 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-7c556cf5c6dd49e494507630ed60e2d62025-01-09T06:16:06ZengElsevierOral Oncology Reports2772-90602024-06-0110100404Biotechnology breakthroughs: Revolutionizing oral cancer treatmentSafin Hussein0Karzan Qurbani1Haider Hamzah2Seenaa Ali3Sirwan Khalid Ahmed4Department of Biology, College of Science, University of Raparin, Rania, Sulaymaniyah, 46012, IraqCorresponding author. Department of Biology, College of Science, University of Raparin, Rania, Sulaymaniyah, 46012, Iraq.; Department of Biology, College of Science, University of Raparin, Rania, Sulaymaniyah, 46012, IraqDepartment of Biology, College of Science, University of Sulaimani, Sulaymaniyah, Kurdistan Region, IraqDepartment of Medical Laboratory, College of Health and Medical Technologies, Sulaimani Polytechnic University, Sulaymaniyah, Kurdistan Region, IraqCollege of Nursing, University of Raparin, Rania, Sulaymaniyah, Kurdistan Region, 46012, IraqOral cancer is a global health concern due to its increasing incidence and mortality rates, despite conventional treatments such as surgery, chemotherapy, and radiation therapy. Biotechnology has made significant progress in the management of oral cancer. This essay explores how these advancements are transforming treatment, offering improved outcomes and enhanced quality of life for patients. Targeted therapies, like cetuximab, disrupt specific pathways in cancer cells, inhibiting their proliferation while minimizing damage to healthy cells. This differs from traditional chemotherapy, which has a nonspecific impact. Immunotherapy, using checkpoint inhibitors like pembrolizumab and nivolumab, enhances the body's immune response against oral cancer cells, particularly in cases resistant to conventional treatment. Gene therapy holds promise in correcting genetic abnormalities that contribute to tumor growth or enhancing the immune system's ability to eradicate cancer cells. Oncolytic viruses and CRISPR-Cas9 are among the tools leading the way in personalized interventions. Liquid biopsies, which analyze circulating tumor cells and biomarkers, provide a non-invasive method for diagnosing and monitoring oral cancer. Integration with advanced bioinformatics and artificial intelligence enables precision medicine tailored to individual tumors. Collectively, these advancements offer hope for transforming oral cancer into a manageable condition. Achieving this goal requires collaborative efforts and continued exploration to optimize treatment effectiveness and elevate patient survival rates.http://www.sciencedirect.com/science/article/pii/S2772906024002504Oral cancerBiotechnologyTargeted therapiesImmunotherapyGene therapyLiquid biopsies |
| spellingShingle | Safin Hussein Karzan Qurbani Haider Hamzah Seenaa Ali Sirwan Khalid Ahmed Biotechnology breakthroughs: Revolutionizing oral cancer treatment Oral Oncology Reports Oral cancer Biotechnology Targeted therapies Immunotherapy Gene therapy Liquid biopsies |
| title | Biotechnology breakthroughs: Revolutionizing oral cancer treatment |
| title_full | Biotechnology breakthroughs: Revolutionizing oral cancer treatment |
| title_fullStr | Biotechnology breakthroughs: Revolutionizing oral cancer treatment |
| title_full_unstemmed | Biotechnology breakthroughs: Revolutionizing oral cancer treatment |
| title_short | Biotechnology breakthroughs: Revolutionizing oral cancer treatment |
| title_sort | biotechnology breakthroughs revolutionizing oral cancer treatment |
| topic | Oral cancer Biotechnology Targeted therapies Immunotherapy Gene therapy Liquid biopsies |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024002504 |
| work_keys_str_mv | AT safinhussein biotechnologybreakthroughsrevolutionizingoralcancertreatment AT karzanqurbani biotechnologybreakthroughsrevolutionizingoralcancertreatment AT haiderhamzah biotechnologybreakthroughsrevolutionizingoralcancertreatment AT seenaaali biotechnologybreakthroughsrevolutionizingoralcancertreatment AT sirwankhalidahmed biotechnologybreakthroughsrevolutionizingoralcancertreatment |