Angiogenesis in squamous precancerous cervical lesions
Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between stromal angiogenesis and the grade of ce...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2007-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701007P.pdf |
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| author | Panjković Milan Ivković-Kapicl Tatjana |
| author_facet | Panjković Milan Ivković-Kapicl Tatjana |
| author_sort | Panjković Milan |
| collection | DOAJ |
| description | Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between stromal angiogenesis and the grade of cervical intraepithelial changes (CIN). Methods. The tissue sections of 50 cone biopsies were immunohistochemically stained for CD31 antigen, a marker for endothelial cells. All microvessels along the basement membrane subtending dysplastic epithelium were counted. The mean microvessel count was calculated from the three separate fields for each specimen. All the cases were devided into four groups: normal cervical epithelium (n = 5), CIN1 (n = 7), CIN2 (n = 13), and CIN3 (n = 25). Results. The mean microvessel count (MVC) under the dysplastic epithelium was 18.1. For the patients with CIN1 changes the mean MVC was 12.9, while this number was 18.72 and 19.24 for the patients with CIN2 and CIN3 grade of epithelial changes, respectively. In a subset of the high grade lesions vascular structures were also noted in the upper layer of the epithelium. The mean MVC in the cases with the presence of these structures was 22, while this number was 12.91 in the cases without intraepithelial vessels. Although we found an increase of the mean MVC with the increase of the CIN grade, statistically significant differences were found out between CIN1 and CIN3 lesions. The mean MVC of the patients with the presence of intraepithelial vessels was statistically higher than the mean MVC of the patients without these structures. Conclusion. On the basis of the obtained results, we can conclude that the mean MVC and CIN grade positively correlated, while the number of cases with intraepithelial vessels increased with the CIN grade. |
| format | Article |
| id | doaj-art-7c5464491a5d4bcaa069d7bf58f053d1 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-7c5464491a5d4bcaa069d7bf58f053d12025-08-20T02:06:56ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502007-01-0164171110.2298/VSP0701007PAngiogenesis in squamous precancerous cervical lesionsPanjković MilanIvković-Kapicl TatjanaBackground/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between stromal angiogenesis and the grade of cervical intraepithelial changes (CIN). Methods. The tissue sections of 50 cone biopsies were immunohistochemically stained for CD31 antigen, a marker for endothelial cells. All microvessels along the basement membrane subtending dysplastic epithelium were counted. The mean microvessel count was calculated from the three separate fields for each specimen. All the cases were devided into four groups: normal cervical epithelium (n = 5), CIN1 (n = 7), CIN2 (n = 13), and CIN3 (n = 25). Results. The mean microvessel count (MVC) under the dysplastic epithelium was 18.1. For the patients with CIN1 changes the mean MVC was 12.9, while this number was 18.72 and 19.24 for the patients with CIN2 and CIN3 grade of epithelial changes, respectively. In a subset of the high grade lesions vascular structures were also noted in the upper layer of the epithelium. The mean MVC in the cases with the presence of these structures was 22, while this number was 12.91 in the cases without intraepithelial vessels. Although we found an increase of the mean MVC with the increase of the CIN grade, statistically significant differences were found out between CIN1 and CIN3 lesions. The mean MVC of the patients with the presence of intraepithelial vessels was statistically higher than the mean MVC of the patients without these structures. Conclusion. On the basis of the obtained results, we can conclude that the mean MVC and CIN grade positively correlated, while the number of cases with intraepithelial vessels increased with the CIN grade.http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701007P.pdfcervix uteriprecancerous conditionsneovascularizationpathologic |
| spellingShingle | Panjković Milan Ivković-Kapicl Tatjana Angiogenesis in squamous precancerous cervical lesions Vojnosanitetski Pregled cervix uteri precancerous conditions neovascularization pathologic |
| title | Angiogenesis in squamous precancerous cervical lesions |
| title_full | Angiogenesis in squamous precancerous cervical lesions |
| title_fullStr | Angiogenesis in squamous precancerous cervical lesions |
| title_full_unstemmed | Angiogenesis in squamous precancerous cervical lesions |
| title_short | Angiogenesis in squamous precancerous cervical lesions |
| title_sort | angiogenesis in squamous precancerous cervical lesions |
| topic | cervix uteri precancerous conditions neovascularization pathologic |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701007P.pdf |
| work_keys_str_mv | AT panjkovicmilan angiogenesisinsquamousprecancerouscervicallesions AT ivkovickapicltatjana angiogenesisinsquamousprecancerouscervicallesions |