Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients
[Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombomodulin (TM) levels for LEDVT. [Me...
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Editorial Office of International Journal of Geriatrics
2025-07-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.014&lang=en |
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| _version_ | 1849469576633384960 |
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| author | Chen Jing Zhuge Hengyan Huang Zhihui Wu Lin |
| author_facet | Chen Jing Zhuge Hengyan Huang Zhihui Wu Lin |
| author_sort | Chen Jing |
| collection | DOAJ |
| description | [Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombomodulin (TM) levels for LEDVT. [Methods] Ninety-eight elderly patients who underwent lumbar fusion at the 904th Hospital of the Chinese People’s Liberation Army Joint Support Force from July 2021 to July 2024 were retrospectively selected and divided into the occurrence group (23 cases) and the non-occurrence group (75 cases) according to whether LEDVT occurred within 14 d after surgery. All patients underwent MHR and TM examination before operation, and the relevant data were collected for comparison. Multivariate Logistic regression model was used to analyze the influencing factors of postoperative LEDVT. ROC curve was used to analyze the predictive value of MHR and TM for postoperative LEDVT in patients. [Results] The proportion of patients aged ≥75 years, smoking, diabetes, D-dimer (D-D) level, postoperative bed-rest time ≥5 d, MHR level, and TM level in the occurrence group were higher than those in the non-occurrence group (P<0.05). Multivariate logistic regression model results showed that age (OR=3.612, 95%CI: 1.273-10.247), postoperative bed-rest time (OR=2.553, 95%CI: 1.248-5.221), D-D level (OR=3.849, 95%CI: 2.092-7.080), MHR level (OR=2.374, 95%CI: 1.452-3.883) and TM level (OR=5.262, 95%CI: 2.324-11.915) were independent risk factors for postoperative LEDVT (P<0.05). The ROC curve showed that the sensitivity of MHR, TM and their combination to predict the occurrence of LEDVT in patients was 69.60%, 78.30% and 91.30%, respectively, and the specificity was 74.70%, 68.00% and 65.30%, respectively, and the area under the curve (AUC) were 0.773, 0.796 and 0.890, respectively (P<0.05). [Conclusion] MHR and TM are independent risk factors for postoperative LEDVT in elderly patients treated with lumbar fusion, and combined clinical tests have higher sensitivity but lower specificity in assessing the risk of LEDVT in patients. |
| format | Article |
| id | doaj-art-7c53b31fb7d149e8bcd882d12ab4cefd |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-7c53b31fb7d149e8bcd882d12ab4cefd2025-08-20T03:25:26ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-07-0146445746210.3969/j.issn.1674-7593.2025.04.014Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patientsChen Jing0Zhuge Hengyan1Huang Zhihui2Wu Lin3Department of Orthopedics, 904th Hospital of the Chinese People’s Liberation Army Joint Support Force, Wuxi 214000Department of Orthopedics, 904th Hospital of the Chinese People’s Liberation Army Joint Support Force, Wuxi 214000Department of Orthopedics, 904th Hospital of the Chinese People’s Liberation Army Joint Support Force, Wuxi 214000Department of Orthopedics, 904th Hospital of the Chinese People’s Liberation Army Joint Support Force, Wuxi 214000[Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombomodulin (TM) levels for LEDVT. [Methods] Ninety-eight elderly patients who underwent lumbar fusion at the 904th Hospital of the Chinese People’s Liberation Army Joint Support Force from July 2021 to July 2024 were retrospectively selected and divided into the occurrence group (23 cases) and the non-occurrence group (75 cases) according to whether LEDVT occurred within 14 d after surgery. All patients underwent MHR and TM examination before operation, and the relevant data were collected for comparison. Multivariate Logistic regression model was used to analyze the influencing factors of postoperative LEDVT. ROC curve was used to analyze the predictive value of MHR and TM for postoperative LEDVT in patients. [Results] The proportion of patients aged ≥75 years, smoking, diabetes, D-dimer (D-D) level, postoperative bed-rest time ≥5 d, MHR level, and TM level in the occurrence group were higher than those in the non-occurrence group (P<0.05). Multivariate logistic regression model results showed that age (OR=3.612, 95%CI: 1.273-10.247), postoperative bed-rest time (OR=2.553, 95%CI: 1.248-5.221), D-D level (OR=3.849, 95%CI: 2.092-7.080), MHR level (OR=2.374, 95%CI: 1.452-3.883) and TM level (OR=5.262, 95%CI: 2.324-11.915) were independent risk factors for postoperative LEDVT (P<0.05). The ROC curve showed that the sensitivity of MHR, TM and their combination to predict the occurrence of LEDVT in patients was 69.60%, 78.30% and 91.30%, respectively, and the specificity was 74.70%, 68.00% and 65.30%, respectively, and the area under the curve (AUC) were 0.773, 0.796 and 0.890, respectively (P<0.05). [Conclusion] MHR and TM are independent risk factors for postoperative LEDVT in elderly patients treated with lumbar fusion, and combined clinical tests have higher sensitivity but lower specificity in assessing the risk of LEDVT in patients.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.014&lang=enlumbar vertebrathrombomodulinmonocytehigh-density lipoprotein cholesteroldeep venous thrombosispredictive value |
| spellingShingle | Chen Jing Zhuge Hengyan Huang Zhihui Wu Lin Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients Guoji laonian yixue zazhi lumbar vertebra thrombomodulin monocyte high-density lipoprotein cholesterol deep venous thrombosis predictive value |
| title | Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| title_full | Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| title_fullStr | Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| title_full_unstemmed | Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| title_short | Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| title_sort | influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients |
| topic | lumbar vertebra thrombomodulin monocyte high-density lipoprotein cholesterol deep venous thrombosis predictive value |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.014&lang=en |
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