Influencing factors of lower extremity deep venous thrombosis after lumbar fusion in elderly patients
[Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombomodulin (TM) levels for LEDVT. [Me...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of International Journal of Geriatrics
2025-07-01
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| Series: | Guoji laonian yixue zazhi |
| Subjects: | |
| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.014&lang=en |
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| Summary: | [Objective] To analyze the influencing factors of lower extremity deep venous thrombosis (LEDVT) after lumbar fusion in elderly patients, and to explore the predictive value of peripheral blood monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombomodulin (TM) levels for LEDVT. [Methods] Ninety-eight elderly patients who underwent lumbar fusion at the 904th Hospital of the Chinese People’s Liberation Army Joint Support Force from July 2021 to July 2024 were retrospectively selected and divided into the occurrence group (23 cases) and the non-occurrence group (75 cases) according to whether LEDVT occurred within 14 d after surgery. All patients underwent MHR and TM examination before operation, and the relevant data were collected for comparison. Multivariate Logistic regression model was used to analyze the influencing factors of postoperative LEDVT. ROC curve was used to analyze the predictive value of MHR and TM for postoperative LEDVT in patients. [Results] The proportion of patients aged ≥75 years, smoking, diabetes, D-dimer (D-D) level, postoperative bed-rest time ≥5 d, MHR level, and TM level in the occurrence group were higher than those in the non-occurrence group (P<0.05). Multivariate logistic regression model results showed that age (OR=3.612, 95%CI: 1.273-10.247), postoperative bed-rest time (OR=2.553, 95%CI: 1.248-5.221), D-D level (OR=3.849, 95%CI: 2.092-7.080), MHR level (OR=2.374, 95%CI: 1.452-3.883) and TM level (OR=5.262, 95%CI: 2.324-11.915) were independent risk factors for postoperative LEDVT (P<0.05). The ROC curve showed that the sensitivity of MHR, TM and their combination to predict the occurrence of LEDVT in patients was 69.60%, 78.30% and 91.30%, respectively, and the specificity was 74.70%, 68.00% and 65.30%, respectively, and the area under the curve (AUC) were 0.773, 0.796 and 0.890, respectively (P<0.05). [Conclusion] MHR and TM are independent risk factors for postoperative LEDVT in elderly patients treated with lumbar fusion, and combined clinical tests have higher sensitivity but lower specificity in assessing the risk of LEDVT in patients. |
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| ISSN: | 1674-7593 |