Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study
Introduction: Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis. Endocan and endoglin, biomarkers associated with vascular and inflammatory processes, might play roles in rosacea and cardiovascular comorbidities...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2025-07-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/5015 |
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| author | Melodi Çekiç Ayşın köktürk Lülüfer Tamer Rojda Tanrıverdi |
| author_facet | Melodi Çekiç Ayşın köktürk Lülüfer Tamer Rojda Tanrıverdi |
| author_sort | Melodi Çekiç |
| collection | DOAJ |
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Introduction: Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis. Endocan and endoglin, biomarkers associated with vascular and inflammatory processes, might play roles in rosacea and cardiovascular comorbidities.
Objectives: This study aims to assess serum levels of endocan and endoglin in individuals with rosacea and the function of these biomarkers in indicating comorbidities associated with rosacea.
Methods: A total of 44 patients diagnosed with rosacea and 34 healthy controls were included in this case-control study. The endocan and endoglin levels in serum samples from both groups were measured.
Results: No significant differences in endocan and endoglin levels were observed between the patient and control groups. However, their levels were associated with various clinical features, including symptom and disease severity. A notable association was identified between waist circumference, body mass index and endoglin levels. However, this association was not evident for endocan.
Conclusions: This study suggests endocan and endoglin may play roles in rosacea pathogenesis, with endoglin potentially associated with increased cardiovascular risk.
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| format | Article |
| id | doaj-art-7c53856c050a4feebf2b9af9e903d97f |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-7c53856c050a4feebf2b9af9e903d97f2025-08-20T04:02:51ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-07-0115310.5826/dpc.1503a5015Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control StudyMelodi Çekiç0https://orcid.org/0000-0002-1679-9107Ayşın köktürk1https://orcid.org/0000-0003-3434-9756Lülüfer Tamer2https://orcid.org/0000-0002-0997-0260Rojda Tanrıverdi3https://orcid.org/0000-0002-7004-790Xacıbadem university department of dermatology istanbul turkeyDepartment of Dermatology, Faculty of Medicine, Mersin University, Mersin, TurkeyDepartment of Biochemistry, Faculty of Medicine, Mersin University, Mersin, TurkeyDepartment of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey Introduction: Rosacea, a chronic skin disease characterized by facial redness, is believed to involve inflammation and angiogenesis in its pathogenesis. Endocan and endoglin, biomarkers associated with vascular and inflammatory processes, might play roles in rosacea and cardiovascular comorbidities. Objectives: This study aims to assess serum levels of endocan and endoglin in individuals with rosacea and the function of these biomarkers in indicating comorbidities associated with rosacea. Methods: A total of 44 patients diagnosed with rosacea and 34 healthy controls were included in this case-control study. The endocan and endoglin levels in serum samples from both groups were measured. Results: No significant differences in endocan and endoglin levels were observed between the patient and control groups. However, their levels were associated with various clinical features, including symptom and disease severity. A notable association was identified between waist circumference, body mass index and endoglin levels. However, this association was not evident for endocan. Conclusions: This study suggests endocan and endoglin may play roles in rosacea pathogenesis, with endoglin potentially associated with increased cardiovascular risk. https://dpcj.org/index.php/dpc/article/view/5015Endocanendoglinrosaceainflammationcardiovascular risk |
| spellingShingle | Melodi Çekiç Ayşın köktürk Lülüfer Tamer Rojda Tanrıverdi Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study Dermatology Practical & Conceptual Endocan endoglin rosacea inflammation cardiovascular risk |
| title | Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study |
| title_full | Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study |
| title_fullStr | Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study |
| title_full_unstemmed | Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study |
| title_short | Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control Study |
| title_sort | serum endoglin and endocan levels in rosacea and their association with cardiovascular risk factors a case control study |
| topic | Endocan endoglin rosacea inflammation cardiovascular risk |
| url | https://dpcj.org/index.php/dpc/article/view/5015 |
| work_keys_str_mv | AT melodicekic serumendoglinandendocanlevelsinrosaceaandtheirassociationwithcardiovascularriskfactorsacasecontrolstudy AT aysınkokturk serumendoglinandendocanlevelsinrosaceaandtheirassociationwithcardiovascularriskfactorsacasecontrolstudy AT lulufertamer serumendoglinandendocanlevelsinrosaceaandtheirassociationwithcardiovascularriskfactorsacasecontrolstudy AT rojdatanrıverdi serumendoglinandendocanlevelsinrosaceaandtheirassociationwithcardiovascularriskfactorsacasecontrolstudy |