Population pharmacokinetics and pharmacodynamics of two dosing regimens of antenatal corticosteroids: protocol for a prospective nested study in a randomised controlled trial

Population pharmacokinetics and pharmacodynamics of two dosing regimens of antenatal corticosteroids: protocol for a prospective nested study in a randomised controlled trial

Introduction Antenatal corticosteroid (ACS) regimens have remained unchanged since the initial trials in 1972, with the optimal regimen still undetermined. The WHO ACTION (Antenatal CorticosTeroids for Improving Outcomes in preterm Newborns)-III trial is a three-arm individually randomised double-bl...

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Main Authors: Adejumoke Idowu Ayede, Olufemi T Oladapo, Rekha Bharti, Nitya Wadhwa, Tina Lavin, Nicole Minckas, Ebunoluwa A Adejuyigbe, Shivaprasad S Goudar, William Jusko, Shuchita Gupta, Ayesha De Costa, Adesina Olubukola Adeponle, Ramana Moorthy Aripaka, Francis Olubanji Awoniyi, Nurudeen Ola Bello, Anjali Dabral, Zubair Hasan, Dennis Anthony Isah, Ranjit P Kangle, Wojciech Krzyzanski, Olatunji Okikiola Lawal, Elijah-David Ukpahiu-Ojo Ogwu, Kabir Olatunde Oyeniyi, Amaresh P Patil, Yeshita V Pujar, Subramanian Ramachandran, Sunil Ranga, Ezekiel Onoja Ray, Suresh Sivasankaran, Manjunath S Somannavar, Jyotsna Suri
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/6/e096523.full
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