Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea
<strong>Background:</strong> clinical studies in patients with sickle cell disease have shown that the use of hydroxyurea is associated with a reduction in acute and chronic complications, including those related to the nutritional status of these patients. <br /><strong>Obje...
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Universidad de las Ciencias Médicas de Cienfuegos
2021-03-01
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/976 |
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| author | Belkis Lázara Rodríguez Jorge Lucía Morejón Díaz Yoandra León Rayas María Santa Cruz |
| author_facet | Belkis Lázara Rodríguez Jorge Lucía Morejón Díaz Yoandra León Rayas María Santa Cruz |
| author_sort | Belkis Lázara Rodríguez Jorge |
| collection | DOAJ |
| description | <strong>Background:</strong> clinical studies in patients with sickle cell disease have shown that the use of hydroxyurea is associated with a reduction in acute and chronic complications, including those related to the nutritional status of these patients. <br /><strong>Objective:</strong> to evaluate the nutritional status in patients with sickle cell disease treated with hydroxyurea at the Paquito González Cueto University Pediatric Hospital in Cienfuegos. <br /><strong>Methods:</strong> a descriptive, analytical and prospective study was carried out of all the patients with sickle cell disease treated with hydroxyurea, treated at the Hematology Service of the Pediatric Hospital of Cienfuegos in the period from January 2012 to December 2018. The study variables were: age, sex, hemoglobin variant, clinical manifestations and nutritional evaluation, hematological parameters, hospitalizations and transfusion requirements. The information was obtained from the clinical records. <br /><strong>Results:</strong> 15 patients were studied, there was a predominance of females (60 %) and adolescents represented 80 % of the patients in the study. 10 patients (66.7 %) presented the homozygous form; the Sβ thalassemia and SC variant were represented with 2 and 3 patients, respectively. There were no significant differences when comparing hematological values before and after treatment. A decrease was observed in the frequency and severity of the seizures, in the number of hospitalizations and transfusion requirements in all the patients. Malnutrition was present in only 4 patients out of the total. <br /><strong>Conclusions:</strong> treatment with hydroxyurea for the study patients resulted in clinical improvement, reduction in the number of admissions and decrease in transfusion requirements, which favorably affected their nutritional status. |
| format | Article |
| id | doaj-art-7c4dd9fabab3477c97cc2f409f9c6018 |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2021-03-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-7c4dd9fabab3477c97cc2f409f9c60182025-01-30T21:22:00ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342021-03-011116673498Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with HydroxyureaBelkis Lázara Rodríguez Jorge0Lucía Morejón Díaz1Yoandra León Rayas2María Santa Cruz3Hospital Pediátrico Universitario Paquito González Cueto. Cienfuegos.Hospital Pediátrico Universitario Paquito González Cueto. Cienfuegos.Hospital Pediátrico Universitario Paquito González Cueto. Cienfuegos.Hospital Pediátrico Universitario Paquito González Cueto. Cienfuegos.<strong>Background:</strong> clinical studies in patients with sickle cell disease have shown that the use of hydroxyurea is associated with a reduction in acute and chronic complications, including those related to the nutritional status of these patients. <br /><strong>Objective:</strong> to evaluate the nutritional status in patients with sickle cell disease treated with hydroxyurea at the Paquito González Cueto University Pediatric Hospital in Cienfuegos. <br /><strong>Methods:</strong> a descriptive, analytical and prospective study was carried out of all the patients with sickle cell disease treated with hydroxyurea, treated at the Hematology Service of the Pediatric Hospital of Cienfuegos in the period from January 2012 to December 2018. The study variables were: age, sex, hemoglobin variant, clinical manifestations and nutritional evaluation, hematological parameters, hospitalizations and transfusion requirements. The information was obtained from the clinical records. <br /><strong>Results:</strong> 15 patients were studied, there was a predominance of females (60 %) and adolescents represented 80 % of the patients in the study. 10 patients (66.7 %) presented the homozygous form; the Sβ thalassemia and SC variant were represented with 2 and 3 patients, respectively. There were no significant differences when comparing hematological values before and after treatment. A decrease was observed in the frequency and severity of the seizures, in the number of hospitalizations and transfusion requirements in all the patients. Malnutrition was present in only 4 patients out of the total. <br /><strong>Conclusions:</strong> treatment with hydroxyurea for the study patients resulted in clinical improvement, reduction in the number of admissions and decrease in transfusion requirements, which favorably affected their nutritional status.https://revfinlay.sld.cu/index.php/finlay/article/view/976estudios clínicosestado nutricionalhidroxiurea, niños |
| spellingShingle | Belkis Lázara Rodríguez Jorge Lucía Morejón Díaz Yoandra León Rayas María Santa Cruz Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea Revista Finlay estudios clínicos estado nutricional hidroxiurea, niños |
| title | Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea |
| title_full | Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea |
| title_fullStr | Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea |
| title_full_unstemmed | Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea |
| title_short | Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea |
| title_sort | nutritional evaluation of pediatric patients with sickle cell disease treated with hydroxyurea |
| topic | estudios clínicos estado nutricional hidroxiurea, niños |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/976 |
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