Harnessing the Microbiome to Enhance Cancer Immunotherapy
The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/368736 |
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| _version_ | 1849408633002000384 |
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| author | Michelle H. Nelson Marshall A. Diven Logan W. Huff Chrystal M. Paulos |
| author_facet | Michelle H. Nelson Marshall A. Diven Logan W. Huff Chrystal M. Paulos |
| author_sort | Michelle H. Nelson |
| collection | DOAJ |
| description | The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies. |
| format | Article |
| id | doaj-art-7c49c95806da4fcf9ca0fe05d6590303 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7c49c95806da4fcf9ca0fe05d65903032025-08-20T03:35:44ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/368736368736Harnessing the Microbiome to Enhance Cancer ImmunotherapyMichelle H. Nelson0Marshall A. Diven1Logan W. Huff2Chrystal M. Paulos3Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USAThe microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies.http://dx.doi.org/10.1155/2015/368736 |
| spellingShingle | Michelle H. Nelson Marshall A. Diven Logan W. Huff Chrystal M. Paulos Harnessing the Microbiome to Enhance Cancer Immunotherapy Journal of Immunology Research |
| title | Harnessing the Microbiome to Enhance Cancer Immunotherapy |
| title_full | Harnessing the Microbiome to Enhance Cancer Immunotherapy |
| title_fullStr | Harnessing the Microbiome to Enhance Cancer Immunotherapy |
| title_full_unstemmed | Harnessing the Microbiome to Enhance Cancer Immunotherapy |
| title_short | Harnessing the Microbiome to Enhance Cancer Immunotherapy |
| title_sort | harnessing the microbiome to enhance cancer immunotherapy |
| url | http://dx.doi.org/10.1155/2015/368736 |
| work_keys_str_mv | AT michellehnelson harnessingthemicrobiometoenhancecancerimmunotherapy AT marshalladiven harnessingthemicrobiometoenhancecancerimmunotherapy AT loganwhuff harnessingthemicrobiometoenhancecancerimmunotherapy AT chrystalmpaulos harnessingthemicrobiometoenhancecancerimmunotherapy |