Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice

The nucleoprotein (NP) is a highly conserved internal protein of the influenza virus, a major target for universal influenza vaccine. Our previous studies have proven NP-based subunit vaccine can provide partial protection in mice. It is reported that the protein transduction domain (PTD) TAT protei...

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Main Authors: Yuan Yin, BeiBei Li, Linting Zhou, Jian Luo, Xueying Liu, Shilei Wang, Qun Lu, Wensong Tan, Ze Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
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Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1812436
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author Yuan Yin
BeiBei Li
Linting Zhou
Jian Luo
Xueying Liu
Shilei Wang
Qun Lu
Wensong Tan
Ze Chen
author_facet Yuan Yin
BeiBei Li
Linting Zhou
Jian Luo
Xueying Liu
Shilei Wang
Qun Lu
Wensong Tan
Ze Chen
author_sort Yuan Yin
collection DOAJ
description The nucleoprotein (NP) is a highly conserved internal protein of the influenza virus, a major target for universal influenza vaccine. Our previous studies have proven NP-based subunit vaccine can provide partial protection in mice. It is reported that the protein transduction domain (PTD) TAT protein from human immunodeficiency virus-1 (HIV-1) is able to penetrate cells when added exogenous protein and could effectively enhance the immune response induced by the exogenous protein. In present study, the recombinant protein TAT-NP, a fusion of TAT and NP was effectively expressed in Escherichia coli and purified as a candidate component for an influenza vaccine. We evaluated the immunogenicity and protective efficacy of recombinant influenza TAT-NP vaccine by intranasal immunization. In vitro experiments showed that TAT-NP could efficiently penetrate into cells. Animal results showed that mice vaccinated with TAT-NP could not only induce higher levels of IgG and mucosal IgA, but also elicit a robust cellular immune response. Moreover, the TAT-NP fusion protein could significantly increase the protection of mice against lethal doses of homologous influenza virus PR8 and could also provide mice protection against a lethal dose challenge against heterosubtypic H9N2 and H3N2 influenza virus. In conclusion, the recombinant TAT-NP might be a universal vaccine candidate against influenza virus.
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spelling doaj-art-7c47512fc4134beda381d2567cf5e9db2025-08-20T02:26:37ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01911933194210.1080/22221751.2020.1812436Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in miceYuan Yin0BeiBei Li1Linting Zhou2Jian Luo3Xueying Liu4Shilei Wang5Qun Lu6Wensong Tan7Ze Chen8Department of Clinical Laboratory, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaDepartment of Clinical Laboratory, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of ChinaState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People’s Republic of ChinaShanghai Institute of Biological Products, Shanghai, People’s Republic of ChinaThe nucleoprotein (NP) is a highly conserved internal protein of the influenza virus, a major target for universal influenza vaccine. Our previous studies have proven NP-based subunit vaccine can provide partial protection in mice. It is reported that the protein transduction domain (PTD) TAT protein from human immunodeficiency virus-1 (HIV-1) is able to penetrate cells when added exogenous protein and could effectively enhance the immune response induced by the exogenous protein. In present study, the recombinant protein TAT-NP, a fusion of TAT and NP was effectively expressed in Escherichia coli and purified as a candidate component for an influenza vaccine. We evaluated the immunogenicity and protective efficacy of recombinant influenza TAT-NP vaccine by intranasal immunization. In vitro experiments showed that TAT-NP could efficiently penetrate into cells. Animal results showed that mice vaccinated with TAT-NP could not only induce higher levels of IgG and mucosal IgA, but also elicit a robust cellular immune response. Moreover, the TAT-NP fusion protein could significantly increase the protection of mice against lethal doses of homologous influenza virus PR8 and could also provide mice protection against a lethal dose challenge against heterosubtypic H9N2 and H3N2 influenza virus. In conclusion, the recombinant TAT-NP might be a universal vaccine candidate against influenza virus.https://www.tandfonline.com/doi/10.1080/22221751.2020.1812436Influenza virusuniversal vaccinenucleoproteinprotein transduction domainnucleoproteincross-protection
spellingShingle Yuan Yin
BeiBei Li
Linting Zhou
Jian Luo
Xueying Liu
Shilei Wang
Qun Lu
Wensong Tan
Ze Chen
Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
Emerging Microbes and Infections
Influenza virus
universal vaccine
nucleoprotein
protein transduction domain
nucleoprotein
cross-protection
title Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
title_full Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
title_fullStr Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
title_full_unstemmed Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
title_short Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice
title_sort protein transduction domain mediated influenza np subunit vaccine generates a potent immune response and protection against influenza virus in mice
topic Influenza virus
universal vaccine
nucleoprotein
protein transduction domain
nucleoprotein
cross-protection
url https://www.tandfonline.com/doi/10.1080/22221751.2020.1812436
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