TOX, through a glass, darkly

The transcription factor TOX has attracted attention in recent years for its role in CD8+ T cell exhaustion. In fact, TOX was known historically for its diverse roles in immune cell biology. Here, we inquire into the basis for this versatility, and propose that one main consideration is that TOX is...

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Bibliographic Details
Main Authors: Patrick G. Hogan, Bruno Villalobos Reveles, Leo Josue Arteaga Vazquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576468/full
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