Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy
Abstract While massive studies are focused on platinum (Pt)‐based nanozyme for antitumor therapies, their therapeutic efficiency is deficient due to the weak catalytic activity in the highly complex tumor microenvironment. Herein, mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt)...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202502688 |
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| author | Fei Cun Jie Chen Hanxue Li Yufang Kou Meiyan Wang Xiaomin Li Hui Chen Jilie Kong |
| author_facet | Fei Cun Jie Chen Hanxue Li Yufang Kou Meiyan Wang Xiaomin Li Hui Chen Jilie Kong |
| author_sort | Fei Cun |
| collection | DOAJ |
| description | Abstract While massive studies are focused on platinum (Pt)‐based nanozyme for antitumor therapies, their therapeutic efficiency is deficient due to the weak catalytic activity in the highly complex tumor microenvironment. Herein, mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) as robust hydroxyl radical and oxygen nanogenerators are achieved for multimodal therapies. Benefiting from the confinement effect of the mesopores in the MGNSs, the Pt nanoclusters (Pt NCs) demonstrate enhanced stability and catalytic activity, with a catalytic constant (Kcat) of 1.42 × 106 s−1, which is 2 and 5 orders magnitude higher than Kcat values of Pt‐decorated non‐porous gold nanoparticles and pure Pt NCs respectively. Density functional theory (DFT) calculations reveal the proper interaction of intermediates contributes to the ultra‐high catalytic activity of MGNSs@Pt. Meanwhile, owing to the local surface plasmon resonance (LSPR) effect in the second near‐infrared (NIR‐II) bio‐window of MGNSs, the nanozymes exhibited high photothermal conversion efficiency up to 43.4%, which enhanced the nanocatalytic damage on cancer cells. This process can induce robust oxidative stress and oxygenation within the tumor, thereby activating the apoptosis pathway for tumor eradication by mitochondrial dysfunction, cell membrane disruption, HIF‐1α downregulation as well as caspase 3 activation, which pave the way for multimodal and effective cancer treatment. |
| format | Article |
| id | doaj-art-7c4556c3bbfc422bb4df11fd5e6730d8 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-7c4556c3bbfc422bb4df11fd5e6730d82025-08-20T03:15:29ZengWileyAdvanced Science2198-38442025-07-011228n/an/a10.1002/advs.202502688Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer TherapyFei Cun0Jie Chen1Hanxue Li2Yufang Kou3Meiyan Wang4Xiaomin Li5Hui Chen6Jilie Kong7Department of Chemistry Fudan University Shanghai 200438 ChinaDepartment of Chemistry Fudan University Shanghai 200438 ChinaDepartment of Chemistry Fudan University Shanghai 200438 ChinaDepartment of Chemistry Fudan University Shanghai 200438 China411 Hospital, School of Medicine Shanghai University Shanghai 200444 ChinaDepartment of Chemistry Fudan University Shanghai 200438 ChinaDepartment of Chemistry Fudan University Shanghai 200438 ChinaDepartment of Chemistry Fudan University Shanghai 200438 ChinaAbstract While massive studies are focused on platinum (Pt)‐based nanozyme for antitumor therapies, their therapeutic efficiency is deficient due to the weak catalytic activity in the highly complex tumor microenvironment. Herein, mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) as robust hydroxyl radical and oxygen nanogenerators are achieved for multimodal therapies. Benefiting from the confinement effect of the mesopores in the MGNSs, the Pt nanoclusters (Pt NCs) demonstrate enhanced stability and catalytic activity, with a catalytic constant (Kcat) of 1.42 × 106 s−1, which is 2 and 5 orders magnitude higher than Kcat values of Pt‐decorated non‐porous gold nanoparticles and pure Pt NCs respectively. Density functional theory (DFT) calculations reveal the proper interaction of intermediates contributes to the ultra‐high catalytic activity of MGNSs@Pt. Meanwhile, owing to the local surface plasmon resonance (LSPR) effect in the second near‐infrared (NIR‐II) bio‐window of MGNSs, the nanozymes exhibited high photothermal conversion efficiency up to 43.4%, which enhanced the nanocatalytic damage on cancer cells. This process can induce robust oxidative stress and oxygenation within the tumor, thereby activating the apoptosis pathway for tumor eradication by mitochondrial dysfunction, cell membrane disruption, HIF‐1α downregulation as well as caspase 3 activation, which pave the way for multimodal and effective cancer treatment.https://doi.org/10.1002/advs.202502688catalytic therapyconfinement effectmesoporous goldplatinum nanozymesphotothermal therapy |
| spellingShingle | Fei Cun Jie Chen Hanxue Li Yufang Kou Meiyan Wang Xiaomin Li Hui Chen Jilie Kong Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy Advanced Science catalytic therapy confinement effect mesoporous gold platinum nanozymes photothermal therapy |
| title | Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy |
| title_full | Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy |
| title_fullStr | Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy |
| title_full_unstemmed | Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy |
| title_short | Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy |
| title_sort | mesoporous gold nanospheres confined platinum nanoclusters as robust ros and oxygen nanogenerators for nir ii hyperthermia cancer therapy |
| topic | catalytic therapy confinement effect mesoporous gold platinum nanozymes photothermal therapy |
| url | https://doi.org/10.1002/advs.202502688 |
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