Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants

Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants

Background Genome‐wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant‐based genome‐wide association studies improving our understanding of the genetics of CAD, the contribution of stru...

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Main Authors: Kruthika R. Iyer, Shoa L. Clarke, Rodrigo Guarischi‐Sousa, Ketrin Gjoni, Adam S. Heath, Erica P. Young, Nathan O. Stitziel, Cecelia Laurie, Jai G. Broome, Alyna T. Khan, Joshua P. Lewis, Huichun Xu, May E. Montasser, Kellan E. Ashley, Natalie R. Hasbani, Eric Boerwinkle, Alanna C. Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M. Lloyd‐Jones, Rozenn N. Lemaitre, Joshua C. Bis, James S. Floyd, Gregory L. Kinney, Donald W. Bowden, Nicholette D. Palmer, Emelia J. Benjamin, Matthew Nayor, Lisa R. Yanek, Brian G. Kral, Lewis C. Becker, Sharon L. R. Kardia, Jennifer A. Smith, Lawrence F. Bielak, Arnita F. Norwood, Yuan‐I Min, April P. Carson, Wendy S. Post, Stephen S. Rich, David Herrington, Xiuqing Guo, Kent D. Taylor, JoAnn E. Manson, Nora Franceschini, Katherine S. Pollard, Braxton D. Mitchell, Ruth J. F. Loos, Myriam Fornage, Lifang Hou, Bruce M. Psaty, Kendra A. Young, Elizabeth A. Regan, Barry I. Freedman, Ramachandran S. Vasan, Daniel Levy, Rasika A. Mathias, Patricia A. Peyser, Laura M. Raffield, Charles Kooperberg, Alex P. Reiner, Jerome I. Rotter, Goo Jun, Paul S. de Vries, Themistocles L. Assimes
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
association testing
coronary artery disease
genetics
structural variants
whole‐genome sequencing
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036499
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