Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry
There is increasing evidence that COVID-19 induces endothelial dysfunction that may precede thrombotic and cardiovascular complications. The aim of this study is to evaluate endothelial function using peripheral arterial tonometry (EndoPAT). The primary endpoint is the hyperemic vascular response in...
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MDPI AG
2024-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/11/1512 |
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| author | Athanasios Moulias Rafail Koros Angeliki Papageorgiou Spyridon Katechis Panagiotis Patrinos Aikaterini Trigka-Vasilakopoulou Athanasios Papageorgiou Ourania Papaioannou Karolina Akinosoglou Georgios Leventopoulos Grigorios Tsigkas Argyrios Tzouvelekis Periklis Davlouros |
| author_facet | Athanasios Moulias Rafail Koros Angeliki Papageorgiou Spyridon Katechis Panagiotis Patrinos Aikaterini Trigka-Vasilakopoulou Athanasios Papageorgiou Ourania Papaioannou Karolina Akinosoglou Georgios Leventopoulos Grigorios Tsigkas Argyrios Tzouvelekis Periklis Davlouros |
| author_sort | Athanasios Moulias |
| collection | DOAJ |
| description | There is increasing evidence that COVID-19 induces endothelial dysfunction that may precede thrombotic and cardiovascular complications. The aim of this study is to evaluate endothelial function using peripheral arterial tonometry (EndoPAT). The primary endpoint is the hyperemic vascular response index (LnRHI) at two months post-discharge. Secondary endpoints include the LnRHI during hospitalization and at six-month follow-up, the proportion of patients with endothelial dysfunction (LnRHI ≤ 0.51), and the incidence of thrombotic events, cardiovascular complications, and mortality during the follow-up period. The study included 23 COVID-19 patients and 22 COVID-19-negative, matched controls. The patients exhibited a significant reduction in the LnRHI at two months post-discharge compared to the controls (median = 0.55 [IQR: 0.49–0.68] vs. median = 0.70 [IQR: 0.62–0.83]; <i>p</i> = 0.012). The difference in the LnRHI between patients and controls was evident from hospitalization and persisted at two and six months without significant temporal changes. The proportion of COVID-19 patients with endothelial dysfunction (LnRHI ≤ 0.51) was 61% during hospitalization and 55% at six months. There was no significant difference in thrombotic or cardiovascular events, nor in mortality. This study demonstrates that COVID-19 adversely affects endothelial function, as evidenced by a reduction in the hyperemic vascular response index, and endothelial dysfunction may also persist. |
| format | Article |
| id | doaj-art-7c2d4a45dc854aa4a49741208d09fd81 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-7c2d4a45dc854aa4a49741208d09fd812025-08-20T01:53:57ZengMDPI AGLife2075-17292024-11-011411151210.3390/life14111512Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial TonometryAthanasios Moulias0Rafail Koros1Angeliki Papageorgiou2Spyridon Katechis3Panagiotis Patrinos4Aikaterini Trigka-Vasilakopoulou5Athanasios Papageorgiou6Ourania Papaioannou7Karolina Akinosoglou8Georgios Leventopoulos9Grigorios Tsigkas10Argyrios Tzouvelekis11Periklis Davlouros12Department of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Rheumatology, General Hospital of Asklipieio Voulas, 16673 Athens, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Pneumonology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Internal Medicine, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Pneumonology, General University Hospital of Patras, 26504 Patras, GreeceDepartment of Cardiology, General University Hospital of Patras, 26504 Patras, GreeceThere is increasing evidence that COVID-19 induces endothelial dysfunction that may precede thrombotic and cardiovascular complications. The aim of this study is to evaluate endothelial function using peripheral arterial tonometry (EndoPAT). The primary endpoint is the hyperemic vascular response index (LnRHI) at two months post-discharge. Secondary endpoints include the LnRHI during hospitalization and at six-month follow-up, the proportion of patients with endothelial dysfunction (LnRHI ≤ 0.51), and the incidence of thrombotic events, cardiovascular complications, and mortality during the follow-up period. The study included 23 COVID-19 patients and 22 COVID-19-negative, matched controls. The patients exhibited a significant reduction in the LnRHI at two months post-discharge compared to the controls (median = 0.55 [IQR: 0.49–0.68] vs. median = 0.70 [IQR: 0.62–0.83]; <i>p</i> = 0.012). The difference in the LnRHI between patients and controls was evident from hospitalization and persisted at two and six months without significant temporal changes. The proportion of COVID-19 patients with endothelial dysfunction (LnRHI ≤ 0.51) was 61% during hospitalization and 55% at six months. There was no significant difference in thrombotic or cardiovascular events, nor in mortality. This study demonstrates that COVID-19 adversely affects endothelial function, as evidenced by a reduction in the hyperemic vascular response index, and endothelial dysfunction may also persist.https://www.mdpi.com/2075-1729/14/11/1512COVID-19-induced endothelial dysfunctionEndoPATreactive hyperemia index in COVID-19 patients |
| spellingShingle | Athanasios Moulias Rafail Koros Angeliki Papageorgiou Spyridon Katechis Panagiotis Patrinos Aikaterini Trigka-Vasilakopoulou Athanasios Papageorgiou Ourania Papaioannou Karolina Akinosoglou Georgios Leventopoulos Grigorios Tsigkas Argyrios Tzouvelekis Periklis Davlouros Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry Life COVID-19-induced endothelial dysfunction EndoPAT reactive hyperemia index in COVID-19 patients |
| title | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry |
| title_full | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry |
| title_fullStr | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry |
| title_full_unstemmed | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry |
| title_short | Assessment of Endothelial Function in Patients with COVID-19 Using Peripheral Arterial Tonometry |
| title_sort | assessment of endothelial function in patients with covid 19 using peripheral arterial tonometry |
| topic | COVID-19-induced endothelial dysfunction EndoPAT reactive hyperemia index in COVID-19 patients |
| url | https://www.mdpi.com/2075-1729/14/11/1512 |
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