Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice
Lead and aluminum are natural components of the Earth's crust and are environmental contaminants. This study was undertaken to evaluate histological alterations induced by a chronic intoxication by aluminum chloride and lead acetate. After 12 weeks in vivo study, an increase in the activity of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University "Hassiba Benbouali" de Chlef
2024-07-01
|
| Series: | Revue Nature et Technologie |
| Online Access: | https://journals.univ-chlef.dz/index.php/natec/article/view/399 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850188612580147200 |
|---|---|
| author | Leila GADOUCHE Khayra ZERROUKI Noureddine DJEBLI |
| author_facet | Leila GADOUCHE Khayra ZERROUKI Noureddine DJEBLI |
| author_sort | Leila GADOUCHE |
| collection | DOAJ |
| description |
Lead and aluminum are natural components of the Earth's crust and are environmental contaminants. This study was undertaken to evaluate histological alterations induced by a chronic intoxication by aluminum chloride and lead acetate. After 12 weeks in vivo study, an increase in the activity of markers of liver function (AST and ALT) was found in blood of treated groups by these metals. Hypocalcaemia has been reported in mice poisoned by lead and hypocalcemia in aluminum-intoxicated group, implying that both metals impair calcium homeostasis. Histological study at the liver level showed hepatocyte lesions with presence of dilated sinusoids, ballooning, inflammatory infiltrates, nuclear pyknosis, Kupffer cells, vascular congestions and increased number of binucleated hepatocytes. The kidneys have dilated renal tubules, inflammatory infiltrates and congestions. The biochemical parameters confirmed the histological changes observed in the liver and kidneys. Lead and aluminum severely affect the liver and kidneys.
|
| format | Article |
| id | doaj-art-7c2a3133b84946f8984969e14d901a4e |
| institution | OA Journals |
| issn | 1112-9778 2437-0312 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | University "Hassiba Benbouali" de Chlef |
| record_format | Article |
| series | Revue Nature et Technologie |
| spelling | doaj-art-7c2a3133b84946f8984969e14d901a4e2025-08-20T02:15:51ZengUniversity "Hassiba Benbouali" de ChlefRevue Nature et Technologie1112-97782437-03122024-07-011602463Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in MiceLeila GADOUCHE0Khayra ZERROUKI1Noureddine DJEBLI2Department of Biology, Faculty of Natural Sciences and Life, Hassiba Benbouali University of Chlef, P.O. Box 151, Chlef 02000, AlgeriaLaboratory of Pharmacognosy and Api-Phytotherapy; Mostaganem University, Mostaganem, AlgeriaLaboratory of Pharmacognosy and Api-Phytotherapy; Mostaganem University, Mostaganem, Algeria Lead and aluminum are natural components of the Earth's crust and are environmental contaminants. This study was undertaken to evaluate histological alterations induced by a chronic intoxication by aluminum chloride and lead acetate. After 12 weeks in vivo study, an increase in the activity of markers of liver function (AST and ALT) was found in blood of treated groups by these metals. Hypocalcaemia has been reported in mice poisoned by lead and hypocalcemia in aluminum-intoxicated group, implying that both metals impair calcium homeostasis. Histological study at the liver level showed hepatocyte lesions with presence of dilated sinusoids, ballooning, inflammatory infiltrates, nuclear pyknosis, Kupffer cells, vascular congestions and increased number of binucleated hepatocytes. The kidneys have dilated renal tubules, inflammatory infiltrates and congestions. The biochemical parameters confirmed the histological changes observed in the liver and kidneys. Lead and aluminum severely affect the liver and kidneys. https://journals.univ-chlef.dz/index.php/natec/article/view/399 |
| spellingShingle | Leila GADOUCHE Khayra ZERROUKI Noureddine DJEBLI Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice Revue Nature et Technologie |
| title | Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice |
| title_full | Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice |
| title_fullStr | Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice |
| title_full_unstemmed | Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice |
| title_short | Lead and Aluminum Toxicity Induce Loss and Death of Hepatorenal Cells in Mice |
| title_sort | lead and aluminum toxicity induce loss and death of hepatorenal cells in mice |
| url | https://journals.univ-chlef.dz/index.php/natec/article/view/399 |
| work_keys_str_mv | AT leilagadouche leadandaluminumtoxicityinducelossanddeathofhepatorenalcellsinmice AT khayrazerrouki leadandaluminumtoxicityinducelossanddeathofhepatorenalcellsinmice AT noureddinedjebli leadandaluminumtoxicityinducelossanddeathofhepatorenalcellsinmice |