RNA-binding proteins as therapeutic targets in cancer
RNA-binding proteins (RBPs) have emerged as critical regulators of cancer progression, influencing virtually all hallmarks of cancer. Their ability to modulate gene expression patterns that promote or inhibit tumorigenesis has positioned RBPs as promising targets for novel anti-cancer therapies. Thi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2025.2470511 |
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| _version_ | 1850140077095649280 |
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| author | Jennifer Jungfleisch Fátima Gebauer |
| author_facet | Jennifer Jungfleisch Fátima Gebauer |
| author_sort | Jennifer Jungfleisch |
| collection | DOAJ |
| description | RNA-binding proteins (RBPs) have emerged as critical regulators of cancer progression, influencing virtually all hallmarks of cancer. Their ability to modulate gene expression patterns that promote or inhibit tumorigenesis has positioned RBPs as promising targets for novel anti-cancer therapies. This mini-review summarizes the current state of RBP-targeted cancer treatments, focusing on five examples, eIF4F, FTO, SF3B1, RBM39 and nucleolin. We highlight the diversity of current targeting approaches and discuss ongoing challenges including the complexity of RBP regulatory networks, potential off-target effects and the need for more specific targeting methods. By assessing the future potential of novel therapeutic avenues, we provide insights into the evolving landscape of cancer treatment and the critical role RBPs may play in next-generation therapeutics. |
| format | Article |
| id | doaj-art-7c1d05bbfb2e474da253f376c8ae000f |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-7c1d05bbfb2e474da253f376c8ae000f2025-08-20T02:29:59ZengTaylor & Francis GroupRNA Biology1547-62861555-85842025-12-012211810.1080/15476286.2025.2470511RNA-binding proteins as therapeutic targets in cancerJennifer Jungfleisch0Fátima Gebauer1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, SpainCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, SpainRNA-binding proteins (RBPs) have emerged as critical regulators of cancer progression, influencing virtually all hallmarks of cancer. Their ability to modulate gene expression patterns that promote or inhibit tumorigenesis has positioned RBPs as promising targets for novel anti-cancer therapies. This mini-review summarizes the current state of RBP-targeted cancer treatments, focusing on five examples, eIF4F, FTO, SF3B1, RBM39 and nucleolin. We highlight the diversity of current targeting approaches and discuss ongoing challenges including the complexity of RBP regulatory networks, potential off-target effects and the need for more specific targeting methods. By assessing the future potential of novel therapeutic avenues, we provide insights into the evolving landscape of cancer treatment and the critical role RBPs may play in next-generation therapeutics.https://www.tandfonline.com/doi/10.1080/15476286.2025.2470511RNA-binding proteinscancertherapeutic targetsASOSMIaptamer |
| spellingShingle | Jennifer Jungfleisch Fátima Gebauer RNA-binding proteins as therapeutic targets in cancer RNA Biology RNA-binding proteins cancer therapeutic targets ASO SMI aptamer |
| title | RNA-binding proteins as therapeutic targets in cancer |
| title_full | RNA-binding proteins as therapeutic targets in cancer |
| title_fullStr | RNA-binding proteins as therapeutic targets in cancer |
| title_full_unstemmed | RNA-binding proteins as therapeutic targets in cancer |
| title_short | RNA-binding proteins as therapeutic targets in cancer |
| title_sort | rna binding proteins as therapeutic targets in cancer |
| topic | RNA-binding proteins cancer therapeutic targets ASO SMI aptamer |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2025.2470511 |
| work_keys_str_mv | AT jenniferjungfleisch rnabindingproteinsastherapeutictargetsincancer AT fatimagebauer rnabindingproteinsastherapeutictargetsincancer |