NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions. RNA 5-methylcytosine (m5C) modification possesses dynamic and reversible nature, suggesting that activity of its methyltransferase NSUN2 is actively...

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Bibliographic Details
Main Authors: Kaifeng Niu, Zixiang Chen, Mengge Li, Guannan Ma, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, Yongliang Zhao
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
NSUN2
Lactylation
RNA 5-methylcytosine
GCLC
Glutathione synthesis
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004579
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