Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury
Abstract Pediatric mild traumatic brain injury (pmTBI) affects millions of youth annually but underlying pathophysiology and time for physiological recovery remains unknown. Non-fasting plasma samples were obtained in 59 pmTBI (28 females; age 14.9 ± 2.7) at approximately 7 days and 4 months post-in...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84053-4 |
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| author | Andrew R. Mayer Tracey V. Wick Jessica R. McQuaid Masen L. Boucher Andrew B. Dodd Cidney R. Robertson-Benta Harm J. van der Horn Erik B. Erhardt Robert E. Sapien Rawan Tarawneh Rebekah Mannix |
| author_facet | Andrew R. Mayer Tracey V. Wick Jessica R. McQuaid Masen L. Boucher Andrew B. Dodd Cidney R. Robertson-Benta Harm J. van der Horn Erik B. Erhardt Robert E. Sapien Rawan Tarawneh Rebekah Mannix |
| author_sort | Andrew R. Mayer |
| collection | DOAJ |
| description | Abstract Pediatric mild traumatic brain injury (pmTBI) affects millions of youth annually but underlying pathophysiology and time for physiological recovery remains unknown. Non-fasting plasma samples were obtained in 59 pmTBI (28 females; age 14.9 ± 2.7) at approximately 7 days and 4 months post-injury and in 41 matched healthy controls (HC: 20 females; age 14.3 ± 2.8). Samples were analyzed for GFAP, NFL, Tau, pTau181 and UCH-L1 protein concentrations in conjunction with a clinical battery. Significant effects of diagnosis (pmTBI > HC) existed at ~ 7 days (p < 0.001; Cohen’s d = 0.72) and ~ 4 months (p = 0.015; Cohen’s d = 0.41) post-injury for NFL. NFL was also elevated in pmTBI with significant alterations to mental status (e.g., post-traumatic amnesia) relative to patients without (p = 0.014; Cohen’s d = 0.77). UCH-L1, GFAP and pTau181 did not differ between groups, but demonstrated negative associations with days post-injury (small to medium effect sizes) suggestive of a more rapid release/clearance. Post-concussive symptoms had the best diagnostic classification accuracy at ~ 7 days, but NFL ranked higher at 4 months post-injury. Preliminary findings highlight dynamic fluctuations in blood-based biomarkers in the first week of pmTBI, with ongoing evidence of protein release (NFL) at 4 months. NFL demonstrated additional promise for delineating injury severity within the spectrum of pmTBI. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-7c1b4d7a358b4adf9aa82aa0deee017a2025-02-09T12:31:52ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-024-84053-4Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injuryAndrew R. Mayer0Tracey V. Wick1Jessica R. McQuaid2Masen L. Boucher3Andrew B. Dodd4Cidney R. Robertson-Benta5Harm J. van der Horn6Erik B. Erhardt7Robert E. Sapien8Rawan Tarawneh9Rebekah Mannix10The Mind Research Network/Lovelace Biomedical and Environmental Research InstituteThe Mind Research Network/Lovelace Biomedical and Environmental Research InstituteThe Mind Research Network/Lovelace Biomedical and Environmental Research InstituteDivision of Emergency MedicineThe Mind Research Network/Lovelace Biomedical and Environmental Research InstituteThe Mind Research Network/Lovelace Biomedical and Environmental Research InstituteThe Mind Research Network/Lovelace Biomedical and Environmental Research InstituteDepartment of Math and Statistics, University of New MexicoDepartments of Psychiatry and Behavioral Sciences, University of New MexicoDepartment of Neurology, University of New MexicoDivision of Emergency MedicineAbstract Pediatric mild traumatic brain injury (pmTBI) affects millions of youth annually but underlying pathophysiology and time for physiological recovery remains unknown. Non-fasting plasma samples were obtained in 59 pmTBI (28 females; age 14.9 ± 2.7) at approximately 7 days and 4 months post-injury and in 41 matched healthy controls (HC: 20 females; age 14.3 ± 2.8). Samples were analyzed for GFAP, NFL, Tau, pTau181 and UCH-L1 protein concentrations in conjunction with a clinical battery. Significant effects of diagnosis (pmTBI > HC) existed at ~ 7 days (p < 0.001; Cohen’s d = 0.72) and ~ 4 months (p = 0.015; Cohen’s d = 0.41) post-injury for NFL. NFL was also elevated in pmTBI with significant alterations to mental status (e.g., post-traumatic amnesia) relative to patients without (p = 0.014; Cohen’s d = 0.77). UCH-L1, GFAP and pTau181 did not differ between groups, but demonstrated negative associations with days post-injury (small to medium effect sizes) suggestive of a more rapid release/clearance. Post-concussive symptoms had the best diagnostic classification accuracy at ~ 7 days, but NFL ranked higher at 4 months post-injury. Preliminary findings highlight dynamic fluctuations in blood-based biomarkers in the first week of pmTBI, with ongoing evidence of protein release (NFL) at 4 months. NFL demonstrated additional promise for delineating injury severity within the spectrum of pmTBI.https://doi.org/10.1038/s41598-024-84053-4Blood-based biomarkersPediatric mild traumatic brain injuryConcussionRecovery |
| spellingShingle | Andrew R. Mayer Tracey V. Wick Jessica R. McQuaid Masen L. Boucher Andrew B. Dodd Cidney R. Robertson-Benta Harm J. van der Horn Erik B. Erhardt Robert E. Sapien Rawan Tarawneh Rebekah Mannix Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury Scientific Reports Blood-based biomarkers Pediatric mild traumatic brain injury Concussion Recovery |
| title | Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury |
| title_full | Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury |
| title_fullStr | Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury |
| title_full_unstemmed | Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury |
| title_short | Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury |
| title_sort | blood based biomarkers suggest prolonged axonal injury following pediatric mild traumatic brain injury |
| topic | Blood-based biomarkers Pediatric mild traumatic brain injury Concussion Recovery |
| url | https://doi.org/10.1038/s41598-024-84053-4 |
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