The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment
Abstract Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). The Hoveyzeh Cohort Study Center provided clinical data for cardiovascular cases. The collection of samples w...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86240-3 |
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| author | Kambiz Ahmadi Angali Majid Farhadi Abdolkazem Neisi Bahman Cheraghian Mehdi Ahmadi Afshin Takdastan Abdolah Dargahi |
| author_facet | Kambiz Ahmadi Angali Majid Farhadi Abdolkazem Neisi Bahman Cheraghian Mehdi Ahmadi Afshin Takdastan Abdolah Dargahi |
| author_sort | Kambiz Ahmadi Angali |
| collection | DOAJ |
| description | Abstract Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). The Hoveyzeh Cohort Study Center provided clinical data for cardiovascular cases. The collection of samples was done randomly. The association between CVD and HMs has been evaluated utilizing seven machine-learning techniques. The results showed that the effect coefficient (β) of bread consumption in the incidence of heart disease is 4.6908 × 10–02. Consumption of bread contaminated with chromium (P value < 0.0217), cadmium (P value < 2.95 × 10–6) and arsenic (P value < 1.15 × 10–07) is significantly related to cardiovascular incidence. Each unit of bread consumption increases As intake by 0.494 (β = 4.940 × 10–01) and CVD incidence by 11.9% (OR = 1.1190). Bread consumption increases Cd intake by 0.479 (β = 4.799 × 10–1) and cardiovascular disease incidence by 11.97% (OR = 1.1197) per unit. The findings indicated that bread intake in the study region is not correlated with non-carcinogenic or carcinogenic risks, since the cancer risk and incremental lifetime cancer risk for both groups were below 1*10^-6. In the present investigation, bread had HMs included As, Cd, Cr, and Pb higher than the limit declared by WHO. The results of the present study showed that bread is a mediating factor (between HMs and the incidence of CVD). |
| format | Article |
| id | doaj-art-7c1a61f6244e4031ac28e60b653f5f04 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7c1a61f6244e4031ac28e60b653f5f042025-01-26T12:33:02ZengNature PortfolioScientific Reports2045-23222025-01-0115111410.1038/s41598-025-86240-3The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessmentKambiz Ahmadi Angali0Majid Farhadi1Abdolkazem Neisi2Bahman Cheraghian3Mehdi Ahmadi4Afshin Takdastan5Abdolah Dargahi6Department of Biostatistics and Epidemiology, School of Health, Social Determinants of Health Research Center, Ahvaz Jundishapur University of Medical SciencesEnvironmental Health Research Center, Lorestan University of Medical SciencesEnvironmental Technologies Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesDepartment of Biostatistics and Epidemiology, Ahvaz Jundishapur University of Medical SciencesEnvironmental Technologies Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesEnvironmental Technologies Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesDepartment of Environmental Health Engineering, Khalkhal University of Medical SciencesAbstract Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). The Hoveyzeh Cohort Study Center provided clinical data for cardiovascular cases. The collection of samples was done randomly. The association between CVD and HMs has been evaluated utilizing seven machine-learning techniques. The results showed that the effect coefficient (β) of bread consumption in the incidence of heart disease is 4.6908 × 10–02. Consumption of bread contaminated with chromium (P value < 0.0217), cadmium (P value < 2.95 × 10–6) and arsenic (P value < 1.15 × 10–07) is significantly related to cardiovascular incidence. Each unit of bread consumption increases As intake by 0.494 (β = 4.940 × 10–01) and CVD incidence by 11.9% (OR = 1.1190). Bread consumption increases Cd intake by 0.479 (β = 4.799 × 10–1) and cardiovascular disease incidence by 11.97% (OR = 1.1197) per unit. The findings indicated that bread intake in the study region is not correlated with non-carcinogenic or carcinogenic risks, since the cancer risk and incremental lifetime cancer risk for both groups were below 1*10^-6. In the present investigation, bread had HMs included As, Cd, Cr, and Pb higher than the limit declared by WHO. The results of the present study showed that bread is a mediating factor (between HMs and the incidence of CVD).https://doi.org/10.1038/s41598-025-86240-3Heart failureCohort studyBreadUrinary |
| spellingShingle | Kambiz Ahmadi Angali Majid Farhadi Abdolkazem Neisi Bahman Cheraghian Mehdi Ahmadi Afshin Takdastan Abdolah Dargahi The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment Scientific Reports Heart failure Cohort study Bread Urinary |
| title | The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| title_full | The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| title_fullStr | The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| title_full_unstemmed | The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| title_short | The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| title_sort | effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment |
| topic | Heart failure Cohort study Bread Urinary |
| url | https://doi.org/10.1038/s41598-025-86240-3 |
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