Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection
Aim. Intravenous leiomyomatosis (IVL) with cardiac extension (CE) is a rare variant of benign uterine leiomyoma. Incomplete resection has a recurrence rate of over 30%. Different hormonal treatments have been described following incomplete resection; however no standard therapy currently exists. We...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/756141 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850220861753131008 |
|---|---|
| author | Mathew P. Doyle Annette Li Claudia I. Villanueva Sheen C. S. Peeceeyen Michael G. Cooper Kevin C. Hanel Gary G. Fermanis Greg Robertson |
| author_facet | Mathew P. Doyle Annette Li Claudia I. Villanueva Sheen C. S. Peeceeyen Michael G. Cooper Kevin C. Hanel Gary G. Fermanis Greg Robertson |
| author_sort | Mathew P. Doyle |
| collection | DOAJ |
| description | Aim. Intravenous leiomyomatosis (IVL) with cardiac extension (CE) is a rare variant of benign uterine leiomyoma. Incomplete resection has a recurrence rate of over 30%. Different hormonal treatments have been described following incomplete resection; however no standard therapy currently exists. We review the literature for medical treatments options following incomplete resection of IVL with CE. Methods. Electronic databases were searched for all studies reporting IVL with CE. These studies were then searched for reports of patients with inoperable or incomplete resection and any further medical treatments. Our database was searched for patients with medical therapy following incomplete resection of IVL with CE and their results were included. Results. All studies were either case reports or case series. Five literature reviews confirm that surgery is the only treatment to achieve cure. The uses of progesterone, estrogen modulation, gonadotropin-releasing hormone antagonism, and aromatase inhibition have been described following incomplete resection. Currently no studies have reviewed the outcomes of these treatments. Conclusions. Complete surgical resection is the only means of cure for IVL with CE, while multiple hormonal therapies have been used with varying results following incomplete resection. Aromatase inhibitors are the only reported treatment to prevent tumor progression or recurrence in patients with incompletely resected IVL with CE. |
| format | Article |
| id | doaj-art-7c1929db19cf4b239f3d92cc0a1f8b1d |
| institution | OA Journals |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-7c1929db19cf4b239f3d92cc0a1f8b1d2025-08-20T02:06:54ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322015-01-01201510.1155/2015/756141756141Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete ResectionMathew P. Doyle0Annette Li1Claudia I. Villanueva2Sheen C. S. Peeceeyen3Michael G. Cooper4Kevin C. Hanel5Gary G. Fermanis6Greg Robertson7Department of Cardiothoracic Surgery, St George Hospital, Sydney, NSW 2217, AustraliaDepartment of Cardiothoracic Surgery, St George Hospital, Sydney, NSW 2217, AustraliaDepartment of Cardiothoracic Surgery, St George Hospital, Sydney, NSW 2217, AustraliaDepartment of Cardiothoracic Surgery, St George Hospital, Sydney, NSW 2217, AustraliaDepartment of Anesthesia, St George Hospital, Sydney, NSW 2217, AustraliaUniversity of New South Wales, Sydney, NSW 2000, AustraliaDepartment of Cardiothoracic Surgery, St George Hospital, Sydney, NSW 2217, AustraliaUniversity of New South Wales, Sydney, NSW 2000, AustraliaAim. Intravenous leiomyomatosis (IVL) with cardiac extension (CE) is a rare variant of benign uterine leiomyoma. Incomplete resection has a recurrence rate of over 30%. Different hormonal treatments have been described following incomplete resection; however no standard therapy currently exists. We review the literature for medical treatments options following incomplete resection of IVL with CE. Methods. Electronic databases were searched for all studies reporting IVL with CE. These studies were then searched for reports of patients with inoperable or incomplete resection and any further medical treatments. Our database was searched for patients with medical therapy following incomplete resection of IVL with CE and their results were included. Results. All studies were either case reports or case series. Five literature reviews confirm that surgery is the only treatment to achieve cure. The uses of progesterone, estrogen modulation, gonadotropin-releasing hormone antagonism, and aromatase inhibition have been described following incomplete resection. Currently no studies have reviewed the outcomes of these treatments. Conclusions. Complete surgical resection is the only means of cure for IVL with CE, while multiple hormonal therapies have been used with varying results following incomplete resection. Aromatase inhibitors are the only reported treatment to prevent tumor progression or recurrence in patients with incompletely resected IVL with CE.http://dx.doi.org/10.1155/2015/756141 |
| spellingShingle | Mathew P. Doyle Annette Li Claudia I. Villanueva Sheen C. S. Peeceeyen Michael G. Cooper Kevin C. Hanel Gary G. Fermanis Greg Robertson Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection International Journal of Vascular Medicine |
| title | Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection |
| title_full | Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection |
| title_fullStr | Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection |
| title_full_unstemmed | Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection |
| title_short | Treatment of Intravenous Leiomyomatosis with Cardiac Extension following Incomplete Resection |
| title_sort | treatment of intravenous leiomyomatosis with cardiac extension following incomplete resection |
| url | http://dx.doi.org/10.1155/2015/756141 |
| work_keys_str_mv | AT mathewpdoyle treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT annetteli treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT claudiaivillanueva treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT sheencspeeceeyen treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT michaelgcooper treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT kevinchanel treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT garygfermanis treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection AT gregrobertson treatmentofintravenousleiomyomatosiswithcardiacextensionfollowingincompleteresection |