Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1

Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1

BackgroundThe human liver-related putative tumor suppressor LPTS/PinX1 is a gene encoding a telomerase inhibitory protein. Overexpression of LPTS/PinX1 protein can inhibit the growth of multiple telomerase-positive cancer cell lines. LPTS/PinX1 has therapeutic potential for cancer.MethodsWe statisti...

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Bibliographic Details
Main Authors: Hongchang Zhou, Xiaoying Zhang, Yao Wang, Yongqiang Wu, Ling Wang, Chen Hu, Ting Zhang, Hui Zhang, Dian You, Mengli Zhao, Mujun Zhao, Anqi Li, Guangming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
LPTS
TPCH
telomerase
telomerase inhibitor
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1643155/full
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