Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes
This review emphasizes the role of oxidative stress in diabetic nephropathy, acting as trigger, modulator, and linker within the complex network of pathologic events. It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/604208 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549803507056640 |
|---|---|
| author | Gina Manda Alexandru-Ionel Checherita Maria Victoria Comanescu Mihail Eugen Hinescu |
| author_facet | Gina Manda Alexandru-Ionel Checherita Maria Victoria Comanescu Mihail Eugen Hinescu |
| author_sort | Gina Manda |
| collection | DOAJ |
| description | This review emphasizes the role of oxidative stress in diabetic nephropathy, acting as trigger, modulator, and linker within the complex network of pathologic events. It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative, and inflammatory stresses. Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation), and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators). Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. Finally, the antioxidant response of renal cells in diabetic nephropathy is tackled, with emphasis on targeted therapy. An integrative approach is needed for identifying key molecular networks which control cellular responses triggered by the array of stressors in diabetic nephropathy. This will foster the discovery of reliable biomarkers for early diagnosis and prognosis, and will guide the discovery of new therapeutic approaches for personalized medicine in diabetic nephropathy. |
| format | Article |
| id | doaj-art-7c07193b64dc4b7d9cc2c35deef1feb1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7c07193b64dc4b7d9cc2c35deef1feb12025-02-03T06:08:36ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/604208604208Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and PodocytesGina Manda0Alexandru-Ionel Checherita1Maria Victoria Comanescu2Mihail Eugen Hinescu3“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania“Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaThis review emphasizes the role of oxidative stress in diabetic nephropathy, acting as trigger, modulator, and linker within the complex network of pathologic events. It highlights key molecular pathways and new hypothesis in diabetic nephropathy, related to the interferences of metabolic, oxidative, and inflammatory stresses. Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation), and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators). Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. Finally, the antioxidant response of renal cells in diabetic nephropathy is tackled, with emphasis on targeted therapy. An integrative approach is needed for identifying key molecular networks which control cellular responses triggered by the array of stressors in diabetic nephropathy. This will foster the discovery of reliable biomarkers for early diagnosis and prognosis, and will guide the discovery of new therapeutic approaches for personalized medicine in diabetic nephropathy.http://dx.doi.org/10.1155/2015/604208 |
| spellingShingle | Gina Manda Alexandru-Ionel Checherita Maria Victoria Comanescu Mihail Eugen Hinescu Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes Mediators of Inflammation |
| title | Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes |
| title_full | Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes |
| title_fullStr | Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes |
| title_full_unstemmed | Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes |
| title_short | Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes |
| title_sort | redox signaling in diabetic nephropathy hypertrophy versus death choices in mesangial cells and podocytes |
| url | http://dx.doi.org/10.1155/2015/604208 |
| work_keys_str_mv | AT ginamanda redoxsignalingindiabeticnephropathyhypertrophyversusdeathchoicesinmesangialcellsandpodocytes AT alexandruionelchecherita redoxsignalingindiabeticnephropathyhypertrophyversusdeathchoicesinmesangialcellsandpodocytes AT mariavictoriacomanescu redoxsignalingindiabeticnephropathyhypertrophyversusdeathchoicesinmesangialcellsandpodocytes AT mihaileugenhinescu redoxsignalingindiabeticnephropathyhypertrophyversusdeathchoicesinmesangialcellsandpodocytes |