Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs

Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs

Type 2 diabetes mellitus (T2DM) is an obesity-related disease claiming substantial global mortality annually. Current animal models of T2DM remain limited, with low success rates in establishing porcine models of high-fat diet (HFD)-induced T2DM. Our experimental design employed 35 Guizhou mini-pigs...

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Bibliographic Details
Main Authors: Yanjun Wu, Jiayuan Mo, Qianguang Wang, Jialong Li, Jia Wei, Nuo Zhang, Yuanqiu Dong, Xiang Zhu, Taofeng Lu, Sicheng Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
type 2 diabetes
high-fat diet
microbiome
metabolome
Guizhou mini-pig
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1555069/full
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