Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis
Introduction: Viral hepatitis and other liver-related diseases are mostly difficult to diagnose solely based on clinical regimes. Liver damage results in alterations in serum enzyme patterns which have been used to develop many enzyme-based assays. Aim and objectives: The major clinical consequences...
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Jaypee Brothers Medical Publisher
2023-08-01
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| Series: | Indian Journal of Medical Biochemistry |
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| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0208 |
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| author | Poonam Jain Anil Kumar Batta Pashaura Singh |
| author_facet | Poonam Jain Anil Kumar Batta Pashaura Singh |
| author_sort | Poonam Jain |
| collection | DOAJ |
| description | Introduction: Viral hepatitis and other liver-related diseases are mostly difficult to diagnose solely based on clinical regimes. Liver damage results in alterations in serum enzyme patterns which have been used to develop many enzyme-based assays.
Aim and objectives: The major clinical consequences of chronic liver disease can be evaluated by liver function tests like bilirubin, gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine transaminase (ALT). Alanine transaminase and AST changes indicate leakage from damaged hepatocytes. The present study was conducted to compare the serum levels of GGT, AST, ALT, AST:ALT ratio, and bilirubin in patients with chronic hepatitis.
Materials and methods: The study group comprised 100 clinically diagnosed patients with chronic hepatitis and 100 controls.
Results: Case–control comparison showed statistically higher values of GGT (<italic>p</italic> < 0.01), AST (<italic>p</italic> < 0.05), ALT (<italic>p</italic> < 0.05), AST:ALT (<italic>p</italic> < 0.01), and bilirubin (<italic>p</italic> < 0.05) in cases and serum levels of GGT, AST:ALT, and bilirubin were sensitive and specific when various parameters were compared with each other in various hepatitis and controls.
Conclusion: The present study indicates that the parameters GGT, AST, ALT, AST:ALT ratio, and bilirubin are associated with increased risk of hepatitis.
Clinical significance: The serum levels of GGT, AST, ALT, AST:ALT ratio, and bilirubin can be used for the biochemical profiling of different types of patients with hepatitis. |
| format | Article |
| id | doaj-art-7bfd43635ced4eb9be21095da9d2ff8f |
| institution | DOAJ |
| issn | 0972-1207 2456-5164 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-7bfd43635ced4eb9be21095da9d2ff8f2025-08-20T03:18:18ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry0972-12072456-51642023-08-01263737610.5005/jp-journals-10054-02081Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic HepatitisPoonam Jain0Anil Kumar Batta1Pashaura Singh2Poonam Jain, Department of Biochemistry, Government Medical College, Amritsar, Punjab, India, Phone: +91 9914119992Department of Biochemistry, Government Medical College, Amritsar, Punjab, IndiaDepartment of Medicine, Government Medical College, Amritsar, Punjab, IndiaIntroduction: Viral hepatitis and other liver-related diseases are mostly difficult to diagnose solely based on clinical regimes. Liver damage results in alterations in serum enzyme patterns which have been used to develop many enzyme-based assays. Aim and objectives: The major clinical consequences of chronic liver disease can be evaluated by liver function tests like bilirubin, gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine transaminase (ALT). Alanine transaminase and AST changes indicate leakage from damaged hepatocytes. The present study was conducted to compare the serum levels of GGT, AST, ALT, AST:ALT ratio, and bilirubin in patients with chronic hepatitis. Materials and methods: The study group comprised 100 clinically diagnosed patients with chronic hepatitis and 100 controls. Results: Case–control comparison showed statistically higher values of GGT (<italic>p</italic> < 0.01), AST (<italic>p</italic> < 0.05), ALT (<italic>p</italic> < 0.05), AST:ALT (<italic>p</italic> < 0.01), and bilirubin (<italic>p</italic> < 0.05) in cases and serum levels of GGT, AST:ALT, and bilirubin were sensitive and specific when various parameters were compared with each other in various hepatitis and controls. Conclusion: The present study indicates that the parameters GGT, AST, ALT, AST:ALT ratio, and bilirubin are associated with increased risk of hepatitis. Clinical significance: The serum levels of GGT, AST, ALT, AST:ALT ratio, and bilirubin can be used for the biochemical profiling of different types of patients with hepatitis.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0208alanine transaminaseaspartate aminotransferasebilirubinchronic hepatitisgamma-glutamyl transferase |
| spellingShingle | Poonam Jain Anil Kumar Batta Pashaura Singh Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis Indian Journal of Medical Biochemistry alanine transaminase aspartate aminotransferase bilirubin chronic hepatitis gamma-glutamyl transferase |
| title | Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis |
| title_full | Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis |
| title_fullStr | Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis |
| title_full_unstemmed | Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis |
| title_short | Comparative Study of Serum Levels of Gamma-glutamyl Transferase, Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), AST:ALT, and Bilirubin in Patients with Chronic Hepatitis |
| title_sort | comparative study of serum levels of gamma glutamyl transferase aspartate aminotransferase ast alanine transaminase alt ast alt and bilirubin in patients with chronic hepatitis |
| topic | alanine transaminase aspartate aminotransferase bilirubin chronic hepatitis gamma-glutamyl transferase |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0208 |
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