Sevoflurane-induced cognitive dysfunction in aged mice mediated by HDAC8-dependent suppression of adult hippocampal neurogenesis via the pCREB/BDNF pathway

Sevoflurane-induced cognitive dysfunction in aged mice mediated by HDAC8-dependent suppression of adult hippocampal neurogenesis via the pCREB/BDNF pathway

Sevoflurane is a widely used anesthetic in elderly patients and has been linked to postoperative cognitive dysfunction; however, its molecular mechanisms remain unclear. Inhibition of adult hippocampal neurogenesis (AHN) and epigenetic alterations, particularly via histone deacetylase 8 (HDAC8), hav...

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Bibliographic Details
Main Authors: Yingxue He, Yanjing Guo, Xiaowei Li, Jiangnan Wu, Zunsai Feng, Gongming Wang, Mengyuan Zhang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
Subjects:
Sevoflurane
Adult hippocampal neurogenesis
Histone acetylation
Cognitive dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025003090
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