Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability
Background. Although known for its efficacy in treatment-resistant schizophrenia, the usage of clozapine has been limited due to concerns over potential adverse effects. Myocarditis, one potential fatal complication, can develop at any point during treatment but has been most commonly observed 2-3 w...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2015/482375 |
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| _version_ | 1850220889954582528 |
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| author | Lila Aboueid Nitin Toteja |
| author_facet | Lila Aboueid Nitin Toteja |
| author_sort | Lila Aboueid |
| collection | DOAJ |
| description | Background. Although known for its efficacy in treatment-resistant schizophrenia, the usage of clozapine has been limited due to concerns over potential adverse effects. Myocarditis, one potential fatal complication, can develop at any point during treatment but has been most commonly observed 2-3 weeks after clozapine initiation. Objective. A case of acute clozapine-induced myocarditis is described, highlighting the history, onset, and treatment course of presentation. There is a need to raise awareness of this potential complication, especially in the pediatric population. Results. 17-year-old Puerto Rican boy, with history of schizophrenia, disorganized type (treatment resistant), and intellectual disability, developed myocarditis on the thirteenth day following clozapine commencement. Initial presenting symptoms included tachycardia, lethargy, and vague gastrointestinal distress. Patient fully recovered after supportive medical care and clozapine discontinuation. Conclusions. Myocarditis is a known potential complication of clozapine initiation; however, due to its limited usage in the pediatric population, reported cases are limited. There is a need to establish evidence-based monitoring guidelines for clozapine usage, particularly in the pediatric population where the presentation may be atypical and clinical suspicion may be overlooked. |
| format | Article |
| id | doaj-art-7bee8e7804e243008a368b6cc239d6a6 |
| institution | OA Journals |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-7bee8e7804e243008a368b6cc239d6a62025-08-20T02:06:53ZengWileyCase Reports in Psychiatry2090-682X2090-68382015-01-01201510.1155/2015/482375482375Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual DisabilityLila Aboueid0Nitin Toteja1Department of Psychiatry, SUNY Downstate Hospital, 450 Clarkson Avenue, Brooklyn, NY 11203, USADepartment of Psychiatry, SUNY Downstate Hospital, 450 Clarkson Avenue, Brooklyn, NY 11203, USABackground. Although known for its efficacy in treatment-resistant schizophrenia, the usage of clozapine has been limited due to concerns over potential adverse effects. Myocarditis, one potential fatal complication, can develop at any point during treatment but has been most commonly observed 2-3 weeks after clozapine initiation. Objective. A case of acute clozapine-induced myocarditis is described, highlighting the history, onset, and treatment course of presentation. There is a need to raise awareness of this potential complication, especially in the pediatric population. Results. 17-year-old Puerto Rican boy, with history of schizophrenia, disorganized type (treatment resistant), and intellectual disability, developed myocarditis on the thirteenth day following clozapine commencement. Initial presenting symptoms included tachycardia, lethargy, and vague gastrointestinal distress. Patient fully recovered after supportive medical care and clozapine discontinuation. Conclusions. Myocarditis is a known potential complication of clozapine initiation; however, due to its limited usage in the pediatric population, reported cases are limited. There is a need to establish evidence-based monitoring guidelines for clozapine usage, particularly in the pediatric population where the presentation may be atypical and clinical suspicion may be overlooked.http://dx.doi.org/10.1155/2015/482375 |
| spellingShingle | Lila Aboueid Nitin Toteja Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability Case Reports in Psychiatry |
| title | Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability |
| title_full | Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability |
| title_fullStr | Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability |
| title_full_unstemmed | Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability |
| title_short | Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability |
| title_sort | clozapine induced myocarditis a case report of an adolescent boy with intellectual disability |
| url | http://dx.doi.org/10.1155/2015/482375 |
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