Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study
Introduction: This study investigated the role of fibroblast growth factor 23 (FGF23)/Klotho in the mortality of patients hospitalized with coronavirus disease 2019 (COVID-19), excluding those with chronic kidney disease (CKD). Methodology: A prospective cross-sectional study was conducted from A...
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The Journal of Infection in Developing Countries
2024-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/20272 |
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| author | Davut Akin Burcu B Aydogan Nilufer Emre Gulsah Gundogdu Sehmus Ozmen Ozgen K Erkek Mehmet Alpua |
| author_facet | Davut Akin Burcu B Aydogan Nilufer Emre Gulsah Gundogdu Sehmus Ozmen Ozgen K Erkek Mehmet Alpua |
| author_sort | Davut Akin |
| collection | DOAJ |
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Introduction: This study investigated the role of fibroblast growth factor 23 (FGF23)/Klotho in the mortality of patients hospitalized with coronavirus disease 2019 (COVID-19), excluding those with chronic kidney disease (CKD).
Methodology: A prospective cross-sectional study was conducted from April 2021 to May 2022. Patients who tested positive for COVID-19 via polymerase chain reaction and were hospitalized, were classified into two groups (survivors and non-survivors) at the end of their hospital follow-up. Demographic data, clinical status, and prognosis were analyzed.
Results: A total of 66 patients (age 58.8 ± 17.0 years, 60.6% male) were included. The mean age of non-survivors (67.2 ± 1 years) was significantly higher than the survivors (49.2 ± 1 years; p < 0.0001). FGF23 was significantly elevated in non-survivors (301 ± 20 pg/mL), compared to survivors (160 ± 36 pg/mL; p < 0.0001). Factors with significant differences (p < 0.001) between the two groups were investigated as independent mortality predictors using logistic regression analysis. FGF23 (p = 0.01), age (p = 0.045), and oxygen saturation at admission (p = 0.02) were independent predictors of mortality. High serum FGF23 levels were associated with COVID-19-related mortality; Klotho levels were lower (p = 0.028). Vitamin D was not significantly different between the groups.
Conclusion: Elevated serum FGF23 and parathyroid hormone (PTH), and lower Klotho levels, were associated with COVID-19-related mortality in patients without CKD. There was no association with serum vitamin D levels. Further studies are required to establish the relationship between mortality and FGF23/Klotho, PTH, and vitamin D levels.
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| format | Article |
| id | doaj-art-7bed04840b934749ada0dbbb170bc37a |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-7bed04840b934749ada0dbbb170bc37a2025-08-20T02:57:52ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-12-011812.110.3855/jidc.20272Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective studyDavut Akin0Burcu B Aydogan1Nilufer Emre2Gulsah Gundogdu3Sehmus Ozmen4Ozgen K Erkek5Mehmet Alpua6Department of Nephrology, Pamukkale University School of Medicine, Denizli,TurkeyDepartment of İntensive care, Nazilli State Hospital, Aydin,TurkeyDepartment of Family Medicine, Pamukkale University School of Medicine, Denizli,TurkeyDepartment of Physiology, Pamukkale University School of Medicine, Denizli,TurkeyCamlica Hospital Department of Nephrology, Medipol University, Istanbul,TurkeyDepartment of Physiology, Pamukkale University School of Medicine, Denizli,TurkeyDepartment of Gastroenterology, Pamukkale University School of Medicine, Denizli,Turkey Introduction: This study investigated the role of fibroblast growth factor 23 (FGF23)/Klotho in the mortality of patients hospitalized with coronavirus disease 2019 (COVID-19), excluding those with chronic kidney disease (CKD). Methodology: A prospective cross-sectional study was conducted from April 2021 to May 2022. Patients who tested positive for COVID-19 via polymerase chain reaction and were hospitalized, were classified into two groups (survivors and non-survivors) at the end of their hospital follow-up. Demographic data, clinical status, and prognosis were analyzed. Results: A total of 66 patients (age 58.8 ± 17.0 years, 60.6% male) were included. The mean age of non-survivors (67.2 ± 1 years) was significantly higher than the survivors (49.2 ± 1 years; p < 0.0001). FGF23 was significantly elevated in non-survivors (301 ± 20 pg/mL), compared to survivors (160 ± 36 pg/mL; p < 0.0001). Factors with significant differences (p < 0.001) between the two groups were investigated as independent mortality predictors using logistic regression analysis. FGF23 (p = 0.01), age (p = 0.045), and oxygen saturation at admission (p = 0.02) were independent predictors of mortality. High serum FGF23 levels were associated with COVID-19-related mortality; Klotho levels were lower (p = 0.028). Vitamin D was not significantly different between the groups. Conclusion: Elevated serum FGF23 and parathyroid hormone (PTH), and lower Klotho levels, were associated with COVID-19-related mortality in patients without CKD. There was no association with serum vitamin D levels. Further studies are required to establish the relationship between mortality and FGF23/Klotho, PTH, and vitamin D levels. https://jidc.org/index.php/journal/article/view/20272fibroblast growth factor-23klothoCOVID-19mortalityvitamin D |
| spellingShingle | Davut Akin Burcu B Aydogan Nilufer Emre Gulsah Gundogdu Sehmus Ozmen Ozgen K Erkek Mehmet Alpua Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study Journal of Infection in Developing Countries fibroblast growth factor-23 klotho COVID-19 mortality vitamin D |
| title | Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study |
| title_full | Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study |
| title_fullStr | Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study |
| title_full_unstemmed | Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study |
| title_short | Role of serum fibroblast growth factor-23 and Klotho level in COVID-19 infection-related mortality: a prospective study |
| title_sort | role of serum fibroblast growth factor 23 and klotho level in covid 19 infection related mortality a prospective study |
| topic | fibroblast growth factor-23 klotho COVID-19 mortality vitamin D |
| url | https://jidc.org/index.php/journal/article/view/20272 |
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