The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran.
<h4>Background</h4>Cardiovascular diseases (CVD) are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors includin...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0126779 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849332535818977280 |
|---|---|
| author | Sadaf G Sepanlou Reza Malekzadeh Hossein Poustchi Maryam Sharafkhah Saeed Ghodsi Fatemeh Malekzadeh Arash Etemadi Akram Pourshams Paul D Pharoah Christian C Abnet Paul Brennan Paolo Boffetta Sanford M Dawsey Farin Kamangar |
| author_facet | Sadaf G Sepanlou Reza Malekzadeh Hossein Poustchi Maryam Sharafkhah Saeed Ghodsi Fatemeh Malekzadeh Arash Etemadi Akram Pourshams Paul D Pharoah Christian C Abnet Paul Brennan Paolo Boffetta Sanford M Dawsey Farin Kamangar |
| author_sort | Sadaf G Sepanlou |
| collection | DOAJ |
| description | <h4>Background</h4>Cardiovascular diseases (CVD) are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors including blood markers of lipids. However, risk scoring systems that solely use office-based data, not including laboratory markers, may be advantageous. In the current analysis, we validated the office-based Framingham risk scoring system in Iran.<h4>Methods</h4>The study used data from the Golestan Cohort in North-East of Iran. The following risk factors were used in the development of the risk scoring method: sex, age, body mass index, systolic blood pressure, hypertension treatment, current smoking, and diabetes. Cardiovascular risk functions for prediction of 10-year risk of fatal CVDs were developed.<h4>Results</h4>A total of 46,674 participants free of CVD at baseline were included. Predictive value of estimated risks was examined. The resulting Area Under the ROC Curve (AUC) was 0.774 (95% CI: 0.762-0.787) in all participants, 0.772 (95% CI: 0.753-0.791) in women, and 0.763 (95% CI: 0.747-0.779) in men. AUC was higher in urban areas (0.790, 95% CI: 0.766-0.815). The predicted and observed risks of fatal CVD were similar in women. However, in men, predicted probabilities were higher than observed.<h4>Conclusion</h4>The AUC in the current study is comparable to results of previous studies while lipid profile was replaced by body mass index to develop an office-based scoring system. This scoring algorithm is capable of discriminating individuals at high risk versus low risk of fatal CVD. |
| format | Article |
| id | doaj-art-7bec13cf1fcc4f6fb9abb5ffa10bbb42 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7bec13cf1fcc4f6fb9abb5ffa10bbb422025-08-20T03:46:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012677910.1371/journal.pone.0126779The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran.Sadaf G SepanlouReza MalekzadehHossein PoustchiMaryam SharafkhahSaeed GhodsiFatemeh MalekzadehArash EtemadiAkram PourshamsPaul D PharoahChristian C AbnetPaul BrennanPaolo BoffettaSanford M DawseyFarin Kamangar<h4>Background</h4>Cardiovascular diseases (CVD) are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors including blood markers of lipids. However, risk scoring systems that solely use office-based data, not including laboratory markers, may be advantageous. In the current analysis, we validated the office-based Framingham risk scoring system in Iran.<h4>Methods</h4>The study used data from the Golestan Cohort in North-East of Iran. The following risk factors were used in the development of the risk scoring method: sex, age, body mass index, systolic blood pressure, hypertension treatment, current smoking, and diabetes. Cardiovascular risk functions for prediction of 10-year risk of fatal CVDs were developed.<h4>Results</h4>A total of 46,674 participants free of CVD at baseline were included. Predictive value of estimated risks was examined. The resulting Area Under the ROC Curve (AUC) was 0.774 (95% CI: 0.762-0.787) in all participants, 0.772 (95% CI: 0.753-0.791) in women, and 0.763 (95% CI: 0.747-0.779) in men. AUC was higher in urban areas (0.790, 95% CI: 0.766-0.815). The predicted and observed risks of fatal CVD were similar in women. However, in men, predicted probabilities were higher than observed.<h4>Conclusion</h4>The AUC in the current study is comparable to results of previous studies while lipid profile was replaced by body mass index to develop an office-based scoring system. This scoring algorithm is capable of discriminating individuals at high risk versus low risk of fatal CVD.https://doi.org/10.1371/journal.pone.0126779 |
| spellingShingle | Sadaf G Sepanlou Reza Malekzadeh Hossein Poustchi Maryam Sharafkhah Saeed Ghodsi Fatemeh Malekzadeh Arash Etemadi Akram Pourshams Paul D Pharoah Christian C Abnet Paul Brennan Paolo Boffetta Sanford M Dawsey Farin Kamangar The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. PLoS ONE |
| title | The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. |
| title_full | The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. |
| title_fullStr | The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. |
| title_full_unstemmed | The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. |
| title_short | The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran. |
| title_sort | clinical performance of an office based risk scoring system for fatal cardiovascular diseases in north east of iran |
| url | https://doi.org/10.1371/journal.pone.0126779 |
| work_keys_str_mv | AT sadafgsepanlou theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT rezamalekzadeh theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT hosseinpoustchi theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT maryamsharafkhah theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT saeedghodsi theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT fatemehmalekzadeh theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT arashetemadi theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT akrampourshams theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT pauldpharoah theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT christiancabnet theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT paulbrennan theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT paoloboffetta theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT sanfordmdawsey theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT farinkamangar theclinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT sadafgsepanlou clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT rezamalekzadeh clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT hosseinpoustchi clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT maryamsharafkhah clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT saeedghodsi clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT fatemehmalekzadeh clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT arashetemadi clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT akrampourshams clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT pauldpharoah clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT christiancabnet clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT paulbrennan clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT paoloboffetta clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT sanfordmdawsey clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran AT farinkamangar clinicalperformanceofanofficebasedriskscoringsystemforfatalcardiovasculardiseasesinnortheastofiran |